2-amino-6-chloro-4-(4-methoxyanilino)-1,3,5-triazine | 731831-43-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-6-chloro-4-(4-methoxyanilino)-1,3,5-triazine
• 英文别名: 6-chloro-N-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine；6-chloro-2-N-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine
• CAS: 731831-43-9
• 化学式: C₁₀H₁₀ClN₅O
• mdl: MFCD03730912
• 分子量: 251.675
• InChiKey: KYUQGQRVVRGORQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  86
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-amino-6-chloro-4-(4-methoxyanilino)-1,3,5-triazine 在 tin 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 丙酮 为溶剂， 生成 N-[4-amino-6-(4-methoxyanilino)-1,3,5-triazin-2-yl]-4-(7-chloroquinolin-4-yl)piperazine-1-carbothioamide
  参考文献：
  名称：

  Hybrid 4-Aminoquinoline-1,3,5-triazine Derivatives: Design, Synthesis, Characterization, and Antibacterial Evaluation

  摘要：

  A series of novel 4‐aminoquinoline 1,3,5‐triazine derivatives were synthesized and characterized by FTIR, 1H‐NMR, 13C‐NMR, MS, and elemental analysis. The antibacterial activities of synthesized compounds were tested against three Gram‐positive bacteria, namely Bacillus subtilis (NCIM‐2063), Bacillus cereus (NCIM‐2156), and Staphylococcus aureus (NCIM‐2079), and four Gram‐negative bacteria, namely Proteus vulgaris (NCIM‐2027), Proteus mirabilis (NCIM‐2241), Escherichia coli (NCIM‐2065), and Pseudomonas aeruginosa (NCIM‐2036), using ciprofloxacin as reference standard drug. Results showed compound 9a and 9e as potent antibacterial agents against all bacterial strains except Bacillus cereus (NCIM‐2156). Copyright © 2014 HeteroCorporation

  DOI：

  10.1002/jhet.2210
• 作为产物：
  描述：

  2-氨基-4,6-二氯-S-三嗪 、 甲氧苯胺 以 N-甲基吡咯烷酮 为溶剂， 反应 2.0h， 以80%的产率得到2-amino-6-chloro-4-(4-methoxyanilino)-1,3,5-triazine
  参考文献：
  名称：

  Chemoselective Polycondensation of 2-Amino-4,6-dichloro-1,3,5-triazine with Aromatic Diamines

  摘要：

  研究了 2-氨基-4,6-二氯-1,3,5-三嗪（ADCT）与各种芳香族二胺（如 4,4′-氧二苯胺（ODA）、9、9、9-双（4-氨基苯基）芴（BAFL）、4,4′-（六氟丙烷-2,2-二基）二苯胺（BisAF）和双（4-氨基苯基）砜（SODA）等芳香族二胺进行了研究。ADCT 与 BisAF 的缩聚反应成功地得到了高分子量的完全线性聚鸟嘌呤胺（Mn ≈ 46000），而 ADCT 与 BAFL 的缩聚反应则得到了支化度为 0.02 至 0.17 的支化聚鸟嘌呤胺。

  DOI：

  10.1246/cl.2011.1132

文献信息

• Chemoselective Polycondensation of 2-Amino-4,6-dichloro-1,3,5-triazine with Aromatic Diamines
  作者：Yuji Shibasaki、Takanori Koizumi、Naoya Nishimura、Yoshiyuki Oishi

  DOI：10.1246/cl.2011.1132

  日期：2011.10.5

  Chemoselective polycondensation of 2-amino-4,6-dichloro-1,3,5-triazine (ADCT) was investigated with various aromatic diamines such as 4,4′-oxydianiline (ODA), 9,9-bis(4-aminophenyl)fluorene (BAFL), 4,4′-(hexafluoropropane-2,2-diyl)dianiline (BisAF), and bis(4-aminophenyl)sulfone (SODA) in the presence of potassium carbonate as a base. High-molecular weight perfectly linear polyguanamines (Mn ≈ 46000) were successfully obtained for the polycondensation of ADCT with BisAF, while the polycondensation of ADCT with BAFL afforded branched polyguanamines with a degree of branching of from 0.02 to 0.17.

  研究了 2-氨基-4,6-二氯-1,3,5-三嗪（ADCT）与各种芳香族二胺（如 4,4′-氧二苯胺（ODA）、9、9、9-双（4-氨基苯基）芴（BAFL）、4,4′-（六氟丙烷-2,2-二基）二苯胺（BisAF）和双（4-氨基苯基）砜（SODA）等芳香族二胺进行了研究。ADCT 与 BisAF 的缩聚反应成功地得到了高分子量的完全线性聚鸟嘌呤胺（Mn ≈ 46000），而 ADCT 与 BAFL 的缩聚反应则得到了支化度为 0.02 至 0.17 的支化聚鸟嘌呤胺。
• Hybrid 4-Aminoquinoline-1,3,5-triazine Derivatives: Design, Synthesis, Characterization, and Antibacterial Evaluation
  作者：P. Pathak、A. Thakur、H. R. Bhat、U. P. Singh

  DOI：10.1002/jhet.2210

  日期：2015.7

  A series of novel 4‐aminoquinoline 1,3,5‐triazine derivatives were synthesized and characterized by FTIR, 1H‐NMR, 13C‐NMR, MS, and elemental analysis. The antibacterial activities of synthesized compounds were tested against three Gram‐positive bacteria, namely Bacillus subtilis (NCIM‐2063), Bacillus cereus (NCIM‐2156), and Staphylococcus aureus (NCIM‐2079), and four Gram‐negative bacteria, namely Proteus vulgaris (NCIM‐2027), Proteus mirabilis (NCIM‐2241), Escherichia coli (NCIM‐2065), and Pseudomonas aeruginosa (NCIM‐2036), using ciprofloxacin as reference standard drug. Results showed compound 9a and 9e as potent antibacterial agents against all bacterial strains except Bacillus cereus (NCIM‐2156). Copyright © 2014 HeteroCorporation