2-[5-(Cyclohexen-1-yl)-3-[(4-methylphenyl)methyl]furan-2-yl]-5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-ium | 1384638-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[5-(Cyclohexen-1-yl)-3-[(4-methylphenyl)methyl]furan-2-yl]-5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-ium
• 英文别名: 2-[5-(cyclohexen-1-yl)-3-[(4-methylphenyl)methyl]furan-2-yl]-5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-ium
• CAS: 1384638-45-2
• 化学式: C₂₃H₂₉O₄P
• 分子量: 400.455
• InChiKey: OUHXZHYGFBRENO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  54.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (Z)-2-iodo-3-p-tolylacrylaldehyde 在 silver hexafluoroantimonate 、 copper(l) iodide 、 三苯基膦氯金 、 三乙胺 、 二异丙胺 、 三苯基膦 、 palladium dichloride 作用下， 以 四氢呋喃 、 1,2-二氯乙烷 为溶剂， 反应 6.0h， 生成 2-[5-(Cyclohexen-1-yl)-3-[(4-methylphenyl)methyl]furan-2-yl]-5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-ium
  参考文献：
  名称：

  Efficient AgOTf or Ph3PAuCl–AgSbF6 catalyzed cyclization of 1-hydroxy-2-alkynylallylphosphonates/2-alkynylallyl alcohols to 2-furylphosphonates/2,3,5-trisubstituted furans

  摘要：

  The reaction of 1-hydroxy-2-alkynylallylphosphonates, synthesized by the addition of the corresponding phosphites to 2-alkynylcinnamaldehydes, under AgOTf or Ph3PAuCl-AgSbF6 catalyzed cycloisomerization afforded 2-furylphosphonates in good to excellent yields. These cyclization reactions were compared with those of 2-alkynylallyl alcohols that led to multisubstituted furans. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2012.04.060

文献信息

• Efficient AgOTf or Ph3PAuCl–AgSbF6 catalyzed cyclization of 1-hydroxy-2-alkynylallylphosphonates/2-alkynylallyl alcohols to 2-furylphosphonates/2,3,5-trisubstituted furans
  作者：Ramesh Kotikalapudi、K.C. Kumara Swamy

  DOI：10.1016/j.tetlet.2012.04.060

  日期：2012.7

  The reaction of 1-hydroxy-2-alkynylallylphosphonates, synthesized by the addition of the corresponding phosphites to 2-alkynylcinnamaldehydes, under AgOTf or Ph3PAuCl-AgSbF6 catalyzed cycloisomerization afforded 2-furylphosphonates in good to excellent yields. These cyclization reactions were compared with those of 2-alkynylallyl alcohols that led to multisubstituted furans. (C) 2012 Published by Elsevier Ltd.