7-(3,5-二甲氧基苯基)-1,3-二甲氧基萘 | 927884-96-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 7-(3,5-二甲氧基苯基)-1,3-二甲氧基萘
• 英文名称: 7-(3,5-dimethoxyphenyl)-1,3-dimethoxynaphthalene
• 英文别名: 1,3-dimethoxy-7-(3,5-dimethoxyphenyl)naphthalene；7-(3,5-Dimethoxyphenyl)-1,3-dimethoxynaphthalene
• CAS: 927884-96-6
• 化学式: C₂₀H₂₀O₄
• 分子量: 324.376
• InChiKey: VLOLJMSUXSWPAY-UHFFFAOYSA-N

物化性质

• 沸点：
  479.9±40.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-(3,5-二甲氧基苯基)-1,3-二甲氧基萘 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以27%的产率得到7-(3,5-dihydroxyphenyl)naphthalene-1,3-diol
  参考文献：
  名称：

  Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase

  摘要：

  Oxyresveratrol and resveratrol, with hydroxy substituted trans-stilbene structure, exert potent inhibitory effects on cyclooxygenase, rat liver mitochondrial ATPase activity, and tyrosinase. As the isosteres of oxyresveratrol, a new family of hydroxyl substituted phenyl-naphthalenes were synthesized to show excellent inhibition of mushroom tyrosinase. Compound 10, which is isostere of resveratrol, showed IC50 value of 16.52 mu M in mushroom tyrosinase activity. As compared to this, the reference compound, resveratrol, showed IC50 value of 55.61 mu M. Compound 4, which is isostere of oxyresveratrol, showed IC50 value of 0.49 mu M. Among the other three derivatives, compound 13 showed IC50 value of 0.034 mu M. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.10.025
• 作为产物：
  描述：

  3,5-二甲氧基苄醇 在 吡啶 、 氯化亚砜 、 H3[PW12O40]*13H2O 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 乙醚 、 1,2-二氯乙烷 为溶剂， 反应 29.25h， 生成 7-(3,5-二甲氧基苯基)-1,3-二甲氧基萘
  参考文献：
  名称：

  Dimerization of resveratrol trimethyl ether by phosphotungstic acid, structure confirmation of resformicol A and B

  摘要：

  Dimerization of the trimethyl ether of resveratrol catalyzed by phosphotungstic acid gave two tetralins and a naphthalene derivative. The structure of the tetralins was obtained by X-ray crystallography and confirms the reported stereochemical configuration of resformicol A and B. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2012.04.132

文献信息

• Dimerization of resveratrol trimethyl ether by phosphotungstic acid, structure confirmation of resformicol A and B
  作者：Matthew C. Davis、Thomas J. Groshens

  DOI：10.1016/j.tetlet.2012.04.132

  日期：2012.7

  Dimerization of the trimethyl ether of resveratrol catalyzed by phosphotungstic acid gave two tetralins and a naphthalene derivative. The structure of the tetralins was obtained by X-ray crystallography and confirms the reported stereochemical configuration of resformicol A and B. Published by Elsevier Ltd.
• Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase
  作者：Suhee Song、Hyojin Lee、Youngeup Jin、Young Mi Ha、Sungjin Bae、Hae Young Chung、Hongsuk Suh

  DOI：10.1016/j.bmcl.2006.10.025

  日期：2007.1

  Oxyresveratrol and resveratrol, with hydroxy substituted trans-stilbene structure, exert potent inhibitory effects on cyclooxygenase, rat liver mitochondrial ATPase activity, and tyrosinase. As the isosteres of oxyresveratrol, a new family of hydroxyl substituted phenyl-naphthalenes were synthesized to show excellent inhibition of mushroom tyrosinase. Compound 10, which is isostere of resveratrol, showed IC50 value of 16.52 mu M in mushroom tyrosinase activity. As compared to this, the reference compound, resveratrol, showed IC50 value of 55.61 mu M. Compound 4, which is isostere of oxyresveratrol, showed IC50 value of 0.49 mu M. Among the other three derivatives, compound 13 showed IC50 value of 0.034 mu M. (c) 2006 Elsevier Ltd. All rights reserved.