[(2R,3R,4R,5R)-2-[[(2R,4S)-4-(3-chlorophenyl)-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl]oxymethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-4-methyloxolan-3-yl] 2-aminoacetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(2R,3R,4R,5R)-2-[[(2R,4S)-4-(3-chlorophenyl)-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl]oxymethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-4-methyloxolan-3-yl] 2-aminoacetate
• 英文别名: [(2R,3R,4R,5R)-2-[[(2R,4S)-4-(3-chlorophenyl)-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl]oxymethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-4-methyloxolan-3-yl] 2-aminoacetate
• 化学式: C₂₁H₂₄ClFN₃O₉P
• 分子量: 547.9
• InChiKey: NJQUCPCKDFWOOL-ZMVUDAAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  156
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Derivatives of uridine 5′-cyclophosphate useful to treat hepatitis C viral infections
  申请人：Ligand Pharmaceuticals Incorporated

  公开号：US10000522B2

  公开（公告）日：2018-06-19

  Some embodiments of the present invention include nucleoside 5′-monophosphate derivative compounds, their preparation and their uses. In some embodiments, such compounds are useful to treat hepatitis C viral infections.

  本发明的一些实施方案包括核苷 5′-单磷酸衍生物化合物、其制备方法及其用途。在某些实施方案中，这类化合物可用于治疗丙型肝炎病毒感染。
• DERIVATIVES OF URIDINE 5'-CYCLOPHOSPHATE USEFUL TO TREAT HEPATITIS C VIRAL INFECTIONS
  申请人：LIGAND PHARMACEUTICALS INCORPORATED

  公开号：US20160347783A1

  公开（公告）日：2016-12-01

  Some embodiments of the present invention include nucleoside 5′-monophosphate derivative compounds, their preparation and their uses. In some embodiments, such compounds are useful to treat hepatitis C viral infections.
• US9676809B2
  申请人：——

  公开号：US9676809B2

  公开（公告）日：2017-06-13