3-Pyrrolidino-thiophen | 1074-05-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Pyrrolidino-thiophen
• 英文别名: 3-Pyrrolidinothiophene；1-thiophen-3-ylpyrrolidine
• CAS: 1074-05-1
• 化学式: C₈H₁₁NS
• mdl: MFCD22054248
• 分子量: 153.248
• InChiKey: NRXVFIWZULCQGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Pyrrolidino-thiophen 在 高氯酸 、 三氯氧磷 作用下， 以 乙酸酐 为溶剂， 生成
  参考文献：
  名称：

  Hartmann,H.; Scheithauer,S., Journal fur praktische Chemie (Leipzig 1954), 1969, vol. 311, p. 827 - 843

  摘要：

  DOI：
• 作为产物：
  描述：

  四氢吡咯 、 3-溴噻吩 在 C₂₄H₂₄Cl₂N₄Ni 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 以40 %的产率得到3-Pyrrolidino-thiophen
  参考文献：
  名称：

  萘啶镍配合物催化的光诱导碳-杂原子交叉偶联

  摘要：

  我们描述了由 2,7-二甲基-1,8-萘啶配体支持的 NiII 配合物催化的多功能且实用的光促进 C-N 和 C-O 交叉偶联反应。使用相同的 Ni 催化剂和可见光照射，无需额外的光催化剂即可观察到 C-O 和 C-N 偶联反应性。这些结果表明，镍萘啶配合物代表了光氧化还原镍催化的通用催化基序，可替代常用的联吡啶或多齿配体。

  DOI：

  10.1002/cctc.202301142

文献信息

• Synthesis of some alkylaminothiophene derivatives from 3,4-dibromothiophene and their theoretical calculations
  作者：Emel Ermiş、Halil Berber、Mustafa Güllü

  DOI：10.1016/j.tet.2019.06.049

  日期：2019.8

  catalyzed amination reactions of 3,4-dibromothiophene with some primary, cyclic and acyclic secondary amines were investigated to prepare novel electron rich-thiophenes which are expected to be used as novel N-containing donor type monomer candidates for conductive polymers. In order to obtain better yields, this SNAr type amination reaction was optimized by studying the reaction conditions, such as

  在这项研究中，研究了3,4-二溴噻吩与一些伯，环状和无环仲胺在铜催化下的胺化反应，以制备新型的富电子噻吩，有望用作新型的含氮供体型单体候选导电剂。聚合物。为了获得更好的产量，这个S N通过研究3,4-二溴噻吩与正丁胺之间模型反应的反应条件，如铜催化剂，铜源类型，碱的存在和溶剂的类型，优化了Ar型胺化反应。在优化的反应条件下，以中等收率合成了各种3,4-（N，N'-二烷基氨基）噻吩和3-（N-烷基氨基）噻吩。另外，通过3，4-双（N-丁基氨基）噻吩的环化反应成功地制备了两种新的杂环噻吩衍生物。分离的烷基氨基噻吩的表征通过FTIR，1 H和13进行13 C NMR，GCMS和元素分析。使用DFT / B3LYP / 6-311 + G（2d，p）方法进行所有烷基氨基噻吩的理论计算。
• Compositions and methods for treatment of cancer
  申请人：Li J. Chiang

  公开号：US20060223760A1

  公开（公告）日：2006-10-05

  The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention.

  本发明涉及吡咯喹啉基吡咯-2,5-二酮化合物和吡咯喹啉基吡咯啉-2,5-二酮化合物，以及这些化合物的制备方法。本发明还涉及包含吡咯喹啉基吡咯-2,5-二酮化合物和吡咯喹啉基吡咯啉-2,5-二酮化合物的药物组合物。本发明提供了通过向需要治疗细胞增殖性疾病，如癌症的患者投与本发明的吡咯喹啉基吡咯-2,5-二酮化合物或吡咯喹啉基吡咯啉-2,5-二酮化合物的治疗有效量的方法。
• Compositions and Methods for Treatment of Cancer
  申请人：Li Chiang J.

  公开号：US20100221251A1

  公开（公告）日：2010-09-02

  The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention.

  本发明涉及吡咯喹啉基吡咯-2,5-二酮化合物和吡咯喹啉基吡咯烷-2,5-二酮化合物及其制备方法。本发明还涉及包含吡咯喹啉基吡咯-2,5-二酮化合物和吡咯喹啉基吡咯烷-2,5-二酮化合物的制药组合物。本发明提供了通过向需要治疗细胞增殖性疾病，例如癌症的患者施用本发明的吡咯喹啉基吡咯-2,5-二酮化合物或吡咯喹啉基吡咯烷-2,5-二酮化合物的治疗有效量的方法。
• A mild and practical copper catalyzed amination of halothiophenes
  作者：Zhikuan Lu、Robert J. Twieg

  DOI：10.1016/j.tet.2004.11.017

  日期：2005.1

  We have found that N,N-dimethylethanolamine (deanol) is a useful solvent and ligand for copper catalyzed amination of a variety of unactivated and activated 2- or 3-halothiophenes. Primary amines, acyclic secondary amines, cyclic secondary amines and acyclic secondary amines with 2-hydroxyethyl functionality react with halothiophenes in moderate to excellent yields. The mildly basic conditions utilized are compatible with many functional groups. The animation of halobithiophenes has also been examined. The aminothiophenes produced by this method are important intermediates in a variety of electronic and optoelectronic materials. (C) 2004 Elsevier Ltd. All rights reserved.
• COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
  申请人：ArQule, Inc.

  公开号：US20160355515A1

  公开（公告）日：2016-12-08

  The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds in combination with chemotherapeutic agents. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention and also administering a effective amount of a chemotherapeutic agent.