N-(2-Phenylamino-ethyl)-2-{2-[(2-phenylamino-ethylcarbamoyl)-methoxy]-phenoxy}-acetamide | 919285-33-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(2-Phenylamino-ethyl)-2-{2-[(2-phenylamino-ethylcarbamoyl)-methoxy]-phenoxy}-acetamide
• 英文别名: 2,2'-[1,2-Phenylenebis(oxy)]bis[N-(2-anilinoethyl)acetamide]；N-(2-anilinoethyl)-2-[2-[2-(2-anilinoethylamino)-2-oxoethoxy]phenoxy]acetamide
• CAS: 919285-33-9
• 化学式: C₂₆H₃₀N₄O₄
• 分子量: 462.549
• InChiKey: WUWCSRUPDZRZTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  101
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[[2-[(2-Carbonochloridoylphenoxy)methyl]-4,5-dimethylphenyl]methoxy]benzoyl chloride 、 N-(2-Phenylamino-ethyl)-2-{2-[(2-phenylamino-ethylcarbamoyl)-methoxy]-phenoxy}-acetamide 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 6.0h， 以40%的产率得到6,7-Dimethyl-19,38-diphenyl-2,11,25,32-tetraoxa-19,22,35,38-tetrazapentacyclo[38.4.0.04,9.012,17.026,31]tetratetraconta-1(44),4(9),5,7,12,14,16,26,28,30,40,42-dodecaene-18,23,34,39-tetrone
  参考文献：
  名称：

  Synthesis and study of anti-inflammatory activity of some novel cyclophane amides

  摘要：

  Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.124
• 作为产物：
  描述：

  [2-(2-chloro-2-oxoethoxy)phenoxy]acetyl chloride 、 N-苯基乙二胺 在 TEA 作用下， 以65%的产率得到N-(2-Phenylamino-ethyl)-2-{2-[(2-phenylamino-ethylcarbamoyl)-methoxy]-phenoxy}-acetamide
  参考文献：
  名称：

  Synthesis and study of anti-inflammatory activity of some novel cyclophane amides

  摘要：

  Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.124

文献信息

• Synthesis and study of anti-inflammatory activity of some novel cyclophane amides
  作者：Perumal Rajakumar、A. Mohammed Abdul Rasheed、A. Iman Rabia、D. Chamundeeswari

  DOI：10.1016/j.bmcl.2006.08.124

  日期：2006.12

  Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity. (c) 2006 Elsevier Ltd. All rights reserved.