bacilysin | 154727-79-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bacilysin
• 英文别名: (2S)-2-[[(2S)-2-azaniumylpropanoyl]amino]-3-[(1R,2R,6R)-5-oxo-7-oxabicyclo[4.1.0]heptan-2-yl]propanoate
• CAS: 154727-79-4
• 化学式: C₁₂H₁₈N₂O₅
• 分子量: 270.285
• InChiKey: XFOUAXMJRHNTOP-ZABDLSDTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (S)-2-Benzyloxycarbonylamino-3-((1R,2R,6R)-5-oxo-7-oxa-bicyclo[4.1.0]hept-2-yl)-propionic acid benzyl ester 在 palladium diacetate 、 钯 sodium hydroxide 、 甲酸 、 四丁基氟化铵 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 14.17h， 生成 bacilysin
  参考文献：
  名称：

  Crossley, Maxwell J.; Stamford, Andrew W., Australian Journal of Chemistry, 1993, vol. 46, # 9, p. 1443 - 1446

  摘要：

  DOI：

文献信息

• [EN] ANTIBIOTICS AND METHODS FOR MANUFACTURING THE SAME<br/>[FR] ANTIBIOTIQUES ET PROCÉDÉS POUR LEUR PRÉPARATION
  申请人：UNIV ILLINOIS

  公开号：WO2013002819A1

  公开（公告）日：2013-01-03

  The present invention generally relates to a novel highly discriminating antibiotic, plantazolicin, a plantazolicin-like compound and to pharmaceutical compositions comprising the same. Also provided are methods for producing and using plantazolicin. Due to its bactericidal activity against Bacillus anthracis, plantazolicin and plantazolicin-like compounds can be used in methods for treating and/or preventing anthrax infections.

  本发明总体涉及一种新颖的高度选择性抗生素plantazolicin、一种类似plantazolicin的化合物，以及包含上述化合物的药物组合物。同时，本发明还提供了生产和使用plantazolicin的方法。由于其对炭疽杆菌的杀菌活性，plantazolicin及其类似化合物可用于治疗和/或预防炭疽感染的方法。
• Anti-inflammatory agents
  申请人：Sulfidris S.r.l.

  公开号：EP1832575A1

  公开（公告）日：2007-09-12

  The present invention relates to novel thiosulfonates derivatives. The present invention also provides methods for preventing, treating and/or reducing inflammation-associated diseases in the cardiovascular, connective tissue, pulmonary, gastrointestinal, respiratory, urogenital, nervous or cutaneous systems as well as infective and tumoral diseases employing said compounds.

  本发明涉及新型的硫代硫酸盐衍生物。本发明还提供了使用所述化合物预防、治疗和/或减少心血管、结缔组织、肺、胃肠、呼吸、泌尿生殖、神经或皮肤系统以及感染性和肿瘤性疾病中的炎症相关疾病的方法。
• Process for producing dipeptides or dipeptide derivatives
  申请人：Hashimoto Shin-ichi

  公开号：US20050287627A1

  公开（公告）日：2005-12-29

  The present invention provides a process for producing a dipeptide or a dipeptide derivative using a phosphate donor, a substance selected from the group consisting of adenosine-5′-monophosphate, adenosine-5′-diphosphate and adenosine-5′-triphosphate, one or more kinds of amino acids or amino acid derivatives, and as enzyme sources, a protein having polyphosphate kinase activity, or a culture of cells having the ability to produce the protein or a treated matter of the culture, and a protein having the activity to ATP-dependently form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture.

  本发明提供了一种利用磷酸供体、从腺苷-5′-单磷酸、腺苷-5′-二磷酸和腺苷-5′-三磷酸组成的一组物质中选择的物质、一种或多种氨基酸或氨基酸衍生物，以及作为酶源的具有多磷酸激酶活性的蛋白质，或者具有产生该蛋白质的能力的细胞培养物，以及具有ATP依赖性形成该二肽或二肽衍生物的活性蛋白质，或者具有产生该蛋白质的能力的细胞培养物或经处理的培养物质的生产二肽或二肽衍生物的过程。
• Process For Producing Dipeptides or Dipeptide Derivatives
  申请人：Hashimoto Shin-ichi

  公开号：US20080213827A1

  公开（公告）日：2008-09-04

  The present invention provides a process for producing a dipeptide or a dipeptide derivative by using a protein having the activity to form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture as a enzyme source, which comprise; allowing the enzyme source, one or more kinds of amino acids or amino acid derivatives and ATP to be present in an aqueous medium; allowing the dipeptide or dipeptide derivative to form and accumulate in the medium; and recovering the dipeptide or dipeptide derivative from the medium.

  本发明提供了一种通过利用具有形成二肽或二肽衍生物的活性的蛋白质，从一种或多种氨基酸或氨基酸衍生物中形成二肽或二肽衍生物的过程，或者具有产生该蛋白质的能力的细胞培养物或经处理的培养物作为酶源的方法，包括： 使酶源、一种或多种氨基酸或氨基酸衍生物和ATP存在于水性介质中； 使二肽或二肽衍生物形成并在介质中积累；以及 从介质中回收二肽或二肽衍生物。
• New nuclear transcription factors regulators
  申请人：CTG Pharma S.r.l.

  公开号：EP1645288A1

  公开（公告）日：2006-04-12

  The present invention relates to novel compounds that are nuclear transcription factors (NTF) regulators. The present invention also provides methods for treating, preventing and/or reducing inflammation-associated diseases by regulating NTF in the cardiovascular, connective tissue, pulmonary, gastrointestinal, respiratory, urogenital, nervous, or cutaneous systems as well as tumoral and infective diseases employing said compounds. The present invention is based on the discovery that it is possible to link regulators of NTF to a pharmacologically active compound helpful for treating disorders in the cardiovascular, connective tissue, pulmonary, gastrointestinal, respiratory, urogenital, nervous, or cutaneous systems or tumoral and infective diseases. The resulting compounds have good bioavailability, increased activity and/or safety.

  本发明涉及一种新型化合物，这些化合物是核转录因子（NTF）调节剂。本发明还提供了通过调节心血管、结缔组织、肺部、胃肠、呼吸、泌尿生殖、神经或皮肤系统以及肿瘤和感染性疾病中的NTF来治疗、预防和/或减少与炎症相关疾病的方法。本发明基于这样的发现：可以将NTF的调节剂与对治疗心血管、结缔组织、肺部、胃肠、呼吸、泌尿生殖、神经或皮肤系统或肿瘤和感染性疾病有帮助的药理活性化合物联系起来。由此产生的化合物具有良好的生物利用度、增强的活性和/或安全性。