Methyl 2-(naphthalene-2-carbonylamino)-3-(4-nitrophenyl)propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-(naphthalene-2-carbonylamino)-3-(4-nitrophenyl)propanoate
• 化学式: C21H18N2O5
• 分子量: 378.4
• InChiKey: KOLBWAVLYDRUOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Methods of treating and/or preventing chronic obstructive pulmonary disease
  申请人：UNIVERSITE DE BORDEAUX

  公开号：US10813911B2

  公开（公告）日：2020-10-27

  The present invention relates to a novel composition or method of use for the treatment and/or the prevention of chronic obstructive pulmonary disease (COPD) and acute exacerbations of chronic obstructive pulmonary disease (AECOPDs).

  本发明涉及一种用于治疗和/或预防慢性阻塞性肺病（COPD）和慢性阻塞性肺病急性加重（AECOPDs）的新型组合物或使用方法。
• NEW COMPOSITIONS AND METHODS OF TREATING AND/OR PREVENTING CHRONIC OBSTRUCTIVE PULMONARY DISEASE
  申请人：UNIVERSITE DE BORDEAUX

  公开号：US20180271831A1

  公开（公告）日：2018-09-27

  The present invention relates to a novel composition or method of use for the treatment and/or the prevention of chronic obstructive pulmonary disease (COPD) and acute exacerbations of chronic obstructive pulmonary disease (AECOPDs).
• METHOD OF PROMOTING WOUND HEALING BY INHIBITING CCR3
  申请人：The Board of Regents of the University of Oklahoma

  公开号：US20220041668A1

  公开（公告）日：2022-02-10

  A method of treating a skin wound in a subject by administering at least one inhibitor of C-C chemokine receptor type-3 (CCR3) and/or at least one inhibitor of a CCR3 ligand, thereby causing increased activity of keratinocytes adjacent the skin wound, wherein epithelialization of the skin wound is promoted, and wherein the increased activity of keratinocytes is at least one of (1) increased proliferation of the keratinocytes and (2) increased migration of the keratinocytes adjacent the skin wound. The skin wound may be a chronic wound or an acute wound for example. The inhibitor may be, for example, an antibody or antibody fragment, a small molecule, or an siRNA able to inhibit expression of CCR3.
• [EN] NEW COMPOSITIONS AND METHODS OF TREATING AND/OR PREVENTING CHRONIC OBSTRUCTIVE PULMONARY DISEASE<br/>[FR] NOUVELLES COMPOSITIONS ET MÉTHODES DE TRAITEMENT ET/OU DE PRÉVENTION DE LA MALADIE PULMONAIRE OBSTRUCTIVE CHRONIQUE
  申请人：UNIV BORDEAUX

  公开号：WO2016120369A1

  公开（公告）日：2016-08-04

  The present invention relates to a novel composition or method of use for the treatment and/or the prevention of chronic obstructive pulmonary disease (COPD) and acute exacerbations of chronic obstructive pulmonary disease (AECOPDs).