N-(2-iodophenyl)quinoline-3-carboxamide | 1158180-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-iodophenyl)quinoline-3-carboxamide
• CAS: 1158180-44-9
• 化学式: C₁₆H₁₁IN₂O
• 分子量: 374.181
• InChiKey: QPAZXJIEBNZMPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-iodophenyl)quinoline-3-carboxamide 、 碘甲烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以97%的产率得到N-(2-iodophenyl)-N-methyl-quinoline-3-carboxamide
  参考文献：
  名称：

  Efficient palladium-catalyzed direct arylation of azines and diazines using ligand-free conditions

  摘要：

  The use of the palladium-catalyzed direct arylation was successfully tested on different electron-deficient heterocycles. The results demonstrate the effectiveness of the method based on the intramolecular coupling reaction providing polyazacyclic systems. This new application was obtained by using ligand-free conditions with the mixture of Pd(OAc)(2) and TBAC as catalytic system. With suitable substrates different products arising from regioselective coupling were observed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.02.025
• 作为产物：
  描述：

  喹啉-3-羧酸 、 2-碘苯胺 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以76%的产率得到N-(2-iodophenyl)quinoline-3-carboxamide
  参考文献：
  名称：

  Efficient palladium-catalyzed direct arylation of azines and diazines using ligand-free conditions

  摘要：

  The use of the palladium-catalyzed direct arylation was successfully tested on different electron-deficient heterocycles. The results demonstrate the effectiveness of the method based on the intramolecular coupling reaction providing polyazacyclic systems. This new application was obtained by using ligand-free conditions with the mixture of Pd(OAc)(2) and TBAC as catalytic system. With suitable substrates different products arising from regioselective coupling were observed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.02.025

文献信息

• [EN] STREPTOCOCCUS MUTANS GLUCOSYL TRANSFERASE INHIBITORS FOR DENTAL CARIES THERAPY<br/>[FR] INHIBITEURS DE GLUCOSYLE TRANSFÉRASE DE STREPTOCOCCUS MUTANS POUR LA THÉRAPIE DES CARIES DENTAIRES
  申请人：UAB RESEARCH FOUNDATION

  公开号：WO2019195430A1

  公开（公告）日：2019-10-10

  The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibiting Streptococcus biofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.

  本发明涉及通过抑制葡萄糖基转移酶(Gtf)来抑制链球菌生物膜形成的方法。提供了用于抑制链球菌生物膜形成的化合物、组合物和方法，以及用于预防、抑制和/或治疗龋齿形成的方法，以及用于识别能够预防、抑制和/或治疗龋齿形成的化合物的方法。
• STREPTOCOCCUS MUTANS GLUCOSYL TRANSFERASE INHIBITORS FOR DENTAL CARIES THERAPY
  申请人：UAB Research Foundation

  公开号：US20210115007A1

  公开（公告）日：2021-04-22

  The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibiting Streptococcus biofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.
• Efficient palladium-catalyzed direct arylation of azines and diazines using ligand-free conditions
  作者：Luca Basolo、Egle M. Beccalli、Elena Borsini、Gianluigi Broggini

  DOI：10.1016/j.tet.2009.02.025

  日期：2009.4

  The use of the palladium-catalyzed direct arylation was successfully tested on different electron-deficient heterocycles. The results demonstrate the effectiveness of the method based on the intramolecular coupling reaction providing polyazacyclic systems. This new application was obtained by using ligand-free conditions with the mixture of Pd(OAc)(2) and TBAC as catalytic system. With suitable substrates different products arising from regioselective coupling were observed. (C) 2009 Elsevier Ltd. All rights reserved.