1-(1,2,3-1H-benzotriazol-1-yl)-2-(1-phenylmethyl)-2H-isoindole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 1-(1,2,3-1H-benzotriazol-1-yl)-2-(1-phenylmethyl)-2H-isoindole
• 英文别名: 1-(2-Benzylisoindol-1-yl)benzotriazole
• 化学式: C₂₁H₁₆N₄
• 分子量: 324.385
• InChiKey: VKPMLVZXGCOXRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  35.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  T406石油添加剂 、 苄胺 、 邻苯二甲醛 以 乙腈 为溶剂， 反应 8.0h， 以19.1%的产率得到1-(1,2,3-1H-benzotriazol-1-yl)-2-(1-phenylmethyl)-2H-isoindole
  参考文献：
  名称：

  Preparation of 2-Substituted 1,3-Bis(benzotriazol-1-yl)isoindolines by the Double Mannich Condensation Reaction of o-Phthalaldehyde with Primary Amines in the Presence of 1,2,3-1H-Benzotriazole

  摘要：

  The preparation of isoindolines (1,3-dihydro-2H-isoindoles) possessing two reactive centers as mixed animals is investigated.; In the double Mannich condensation reaction of o-phthalaldehyde with a variety of primary amines in the presence of 1,2,3-1H-benzotriazole (Bt-H) in MeCN, Bt-substituted isoindolines are obtained in fair to good yields when anilines are used as amines.

  DOI：

  10.3987/com-95-7219

文献信息

• Preparation of 2-Substituted 1,3-Bis(benzotriazol-1-yl)isoindolines by the Double Mannich Condensation Reaction of o-Phthalaldehyde with Primary Amines in the Presence of 1,2,3-1H-Benzotriazole
  作者：Ichiro Takahashi、Mikio Tsuzuki、Hiroshi Yokota、Toshio Morita、Hidehiko Kitajima、Kimio Isa

  DOI：10.3987/com-95-7219

  日期：——

  The preparation of isoindolines (1,3-dihydro-2H-isoindoles) possessing two reactive centers as mixed animals is investigated.; In the double Mannich condensation reaction of o-phthalaldehyde with a variety of primary amines in the presence of 1,2,3-1H-benzotriazole (Bt-H) in MeCN, Bt-substituted isoindolines are obtained in fair to good yields when anilines are used as amines.