(4R)-1-[(6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-4-hydroxy-L-proline

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4R)-1-[(6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-4-hydroxy-L-proline
• 英文别名: (2S,4R)-1-[(6,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-4-hydroxypyrrolidine-2-carboxylic acid
• 化学式: C₁₇H₂₀N₂O₄
• 分子量: 316.35
• InChiKey: XOYLGYQCVQWXIE-KGLIPLIRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• SMALL MOLECULE PROMOTING OSTEOBLAST DIFFERENTIATION
  申请人：Cornell University

  公开号：US20220088003A1

  公开（公告）日：2022-03-24

  Provided are compositions and methods for promoting osteogenic differentiation of undifferentiated cells, such as stem cells. An example of a compound useful in the present method is 6,8-dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one (DIPQUO). The present methods can be used for treatment and prevention of bone disorders.