(S)-2-((tert-Butoxycarbonyl)amino)-2-(2,4-dichlorophenyl)acetic acid | 936352-68-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-((tert-Butoxycarbonyl)amino)-2-(2,4-dichlorophenyl)acetic acid
• 英文别名: (2S)-2-(2,4-dichlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid
• CAS: 936352-68-0
• 化学式: C₁₃H₁₅Cl₂NO₄
• 分子量: 320.172
• InChiKey: GAMDFFYPZLOIOI-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.64
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  75.63
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (S)-2-((tert-Butoxycarbonyl)amino)-2-(2,4-dichlorophenyl)acetic acid 在 盐酸 、 4-二甲氨基吡啶 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 62.0h， 生成 C₁₄H₁₁Cl₂N₃O₅S
  参考文献：
  名称：

  Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study

  摘要：

  A novel series of thiazolone-acylsulfonamides were designed as HCV NS5B polymerase allosteric inhibitors. The structure based drug designs (SBDD) were guided by docking results that revealed the potential to explore an additional pocket in the allosteric site. In particular, the designed molecules contain moieties of previously described thiazolone and a newly designed acylsulfonamide linker that is in turn connected with a substituted aromatic ring. The selected compounds were synthesized and demonstrated low mu M activity. The X-ray complex structure was determined at a 2.2 angstrom resolution and converged with the SBDD principle. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.01.024
• 作为产物：
  描述：

  (S)-2-Amino-2-(2,4-dichlorophenyl)acetic acid 、 二碳酸二叔丁酯 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 14.0h， 以73%的产率得到(S)-2-((tert-Butoxycarbonyl)amino)-2-(2,4-dichlorophenyl)acetic acid
  参考文献：
  名称：

  Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study

  摘要：

  A novel series of thiazolone-acylsulfonamides were designed as HCV NS5B polymerase allosteric inhibitors. The structure based drug designs (SBDD) were guided by docking results that revealed the potential to explore an additional pocket in the allosteric site. In particular, the designed molecules contain moieties of previously described thiazolone and a newly designed acylsulfonamide linker that is in turn connected with a substituted aromatic ring. The selected compounds were synthesized and demonstrated low mu M activity. The X-ray complex structure was determined at a 2.2 angstrom resolution and converged with the SBDD principle. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.01.024

文献信息

• Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study
  作者：Shunqi Yan、Todd Appleby、Gary Larson、Jim Z. Wu、Robert K. Hamatake、Zhi Hong、Nanhua Yao

  DOI：10.1016/j.bmcl.2007.01.024

  日期：2007.4

  A novel series of thiazolone-acylsulfonamides were designed as HCV NS5B polymerase allosteric inhibitors. The structure based drug designs (SBDD) were guided by docking results that revealed the potential to explore an additional pocket in the allosteric site. In particular, the designed molecules contain moieties of previously described thiazolone and a newly designed acylsulfonamide linker that is in turn connected with a substituted aromatic ring. The selected compounds were synthesized and demonstrated low mu M activity. The X-ray complex structure was determined at a 2.2 angstrom resolution and converged with the SBDD principle. (c) 2007 Elsevier Ltd. All rights reserved.