4-methoxy-N-methyl-N-(3,4,5-trimethoxyphenyl)benzene-1,3-diamine | 1608474-82-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-methoxy-N-methyl-N-(3,4,5-trimethoxyphenyl)benzene-1,3-diamine
• 英文别名: 4-methoxy-1-N-methyl-1-N-(3,4,5-trimethoxyphenyl)benzene-1,3-diamine
• CAS: 1608474-82-3
• 化学式: C₁₇H₂₂N₂O₄
• 分子量: 318.373
• InChiKey: NVEWFWUCHCEQPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-碘-2-硝基苯甲醚 在 盐酸 、 palladium diacetate 、 铁粉 、 sodium hydride 、 caesium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 、 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 4-methoxy-N-methyl-N-(3,4,5-trimethoxyphenyl)benzene-1,3-diamine
  参考文献：
  名称：

  Discovery of azaisoerianin derivatives as potential antitumors agents

  摘要：

  A series of N-methyl-diarylamines 2 was designed and synthesized as a novel class of CA-4 and isoCA-4 analogues. Compounds 2b and 2m showed excellent antiproliferative activity with mean GI(50) values at a nanomolar level in a diverse set of human cancer cells. These compounds also inhibited tubulin assembly at a micromolar range, arrested the cellular cycle in the G2/M phase and induced apoptosis at very low concentrations. Preliminary in vitro results revealed that 2b and 2m displayed substantial efficacy as potent antivascular agents. Docking studies indicates that these lead compounds showed a binding mode similar to those observed with isoCA-4 at the colchicine binding site of tubulin. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.03.032

文献信息

• Discovery of azaisoerianin derivatives as potential antitumors agents
  作者：Mohamed Ali Soussi、Olivier Provot、Guillaume Bernadat、Jérome Bignon、Joanna Wdzieczak-Bakala、Déborah Desravines、Joëlle Dubois、Jean-Daniel Brion、Samir Messaoudi、Mouad Alami

  DOI：10.1016/j.ejmech.2014.03.032

  日期：2014.5

  A series of N-methyl-diarylamines 2 was designed and synthesized as a novel class of CA-4 and isoCA-4 analogues. Compounds 2b and 2m showed excellent antiproliferative activity with mean GI(50) values at a nanomolar level in a diverse set of human cancer cells. These compounds also inhibited tubulin assembly at a micromolar range, arrested the cellular cycle in the G2/M phase and induced apoptosis at very low concentrations. Preliminary in vitro results revealed that 2b and 2m displayed substantial efficacy as potent antivascular agents. Docking studies indicates that these lead compounds showed a binding mode similar to those observed with isoCA-4 at the colchicine binding site of tubulin. (C) 2014 Elsevier Masson SAS. All rights reserved.