4'-methoxy-2'-methyl-biphenyl-4-carboxylic acid | 108478-29-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-methoxy-2'-methyl-biphenyl-4-carboxylic acid
• 英文别名: 4'-Methoxy-2'-methyl-biphenyl-4-carbonsaeure；4-(4-Methoxy-2-methylphenyl)benzoic acid
• CAS: 108478-29-1
• 化学式: C₁₅H₁₄O₃
• mdl: MFCD11920067
• 分子量: 242.274
• InChiKey: OJZOHUSVEFOVIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4'-methoxy-2'-methyl-biphenyl-4-carboxylic acid 在 吡啶硼烷 、 TEA 、 potassium carbonate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 44.0h， 生成 4'-Methoxy-2'-methyl-biphenyl-4-carboxylic acid {(S)-1-[(R)-3-(3-cyclohexyl-propylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-methyl-amide
  参考文献：
  名称：

  Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

  摘要：

  The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited considerable binding affinity (K-i = 1 nM) and functional activity at MCH-R1, acceptable CYP2D6 inhibition, and good rat brain exposure. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.06.049
• 作为产物：
  描述：

  1-iodo-4-methoxy-2-methylbenzene 、 4-碘苯甲酸甲酯 在 铜 作用下， 生成 4'-methoxy-2'-methyl-biphenyl-4-carboxylic acid
  参考文献：
  名称：

  Sexual competitiveness of Vienna 4/Tol-94 ‘genetic sexing’ sterile mediterranean fruit fly males in Israel

  摘要：

  The sterile insect technique (SIT) is used as an environment-friendly means of suppressing Mediterranean fruit Ay (Ceratitis capitata; 'medfly') populations in the Arava valley of Israel. The technique depends on released sterile males effectively wresting the reproductive potential away from wild, fertile males. Studies carried out in other countries have indicated that sterile males may sometimes be of inferior sexual competitiveness in comparison with their wild counterparts and that this may inhibit SIT efficacy. In the present study, field-cage experiments were conducted to investigate the sexual competitiveness of sterile male medflies (genetic sexing strain Vienna 4/Tol-94) produced in and shipped from Guatemala, in the presence of wild males in Israel. In addition, we checked whether pre-release chilling affects their sexual success. Sterile and wild males were found to be similar in mating frequency, latency until mating, insemination probability, and duration of copulations during which no sperm were stored. There was, however, weak evidence that copulations involving sperm storage were shorter for sterile males. Chilling did not influence any element of male sexual performance. in both experiments, copulations culminating in sperm storage by females were longer than those that failed, suggesting that processes occurring early on in copulation may sometimes be the source of sexual failure. Overall, these results indicate a high standard of vigor in the sterile male medflies used in the SIT program presently followed in Israel.

  DOI：

  10.1007/bf02981808

文献信息

• Sexual competitiveness of Vienna 4/Tol-94 ‘genetic sexing’ sterile mediterranean fruit fly males in Israel
  作者：Phillip W. Taylor、Allon Bear、Yoav Gazit、Yoram Rössler

  DOI：10.1007/bf02981808

  日期：2001.2

  The sterile insect technique (SIT) is used as an environment-friendly means of suppressing Mediterranean fruit Ay (Ceratitis capitata; 'medfly') populations in the Arava valley of Israel. The technique depends on released sterile males effectively wresting the reproductive potential away from wild, fertile males. Studies carried out in other countries have indicated that sterile males may sometimes be of inferior sexual competitiveness in comparison with their wild counterparts and that this may inhibit SIT efficacy. In the present study, field-cage experiments were conducted to investigate the sexual competitiveness of sterile male medflies (genetic sexing strain Vienna 4/Tol-94) produced in and shipped from Guatemala, in the presence of wild males in Israel. In addition, we checked whether pre-release chilling affects their sexual success. Sterile and wild males were found to be similar in mating frequency, latency until mating, insemination probability, and duration of copulations during which no sperm were stored. There was, however, weak evidence that copulations involving sperm storage were shorter for sterile males. Chilling did not influence any element of male sexual performance. in both experiments, copulations culminating in sperm storage by females were longer than those that failed, suggesting that processes occurring early on in copulation may sometimes be the source of sexual failure. Overall, these results indicate a high standard of vigor in the sterile male medflies used in the SIT program presently followed in Israel.
• Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2
  作者：Sarah Hudson、Mehrak Kiankarimi、Martin W. Rowbottom、Troy D. Vickers、Dongpei Wu、Joseph Pontillo、Brett Ching、Wesley Dwight、Val S. Goodfellow、David Schwarz、Christopher E. Heise、Ajay Madan、Jenny Wen、William Ban、Hua Wang、Warren S. Wade

  DOI：10.1016/j.bmcl.2006.06.049

  日期：2006.9

  The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited considerable binding affinity (K-i = 1 nM) and functional activity at MCH-R1, acceptable CYP2D6 inhibition, and good rat brain exposure. (c) 2006 Elsevier Ltd. All rights reserved.