申请人:Bunt Antonius Martinus Gustave
公开号:US20140235631A1
公开(公告)日:2014-08-21
The present invention relates to efflux inhibitor compositions and methods of using these agents for treating conditions where the activity of efflux transporter proteins (e.g., Breast Cancer Resistance Protein (BCRP) and P-Glycoprotein (P-GP)) inhibit effective delivery of a therapeutic agent to a target tissue (e.g., brain, spinal cord, nerves, cerebrospinal fluid, testis, eyeballs, retina, inner ear, placenta, mammary gland, liver, biliary tract, kidney, intestines, lung, adrenal cortex, endometrium, hematopoietic cells, and/or stem cells).
本发明涉及外流抑制剂组合物及使用这些药剂治疗条件的方法,其中外流转运蛋白的活性(例如,乳腺癌耐药蛋白(BCRP)和P-糖蛋白(P-GP))抑制了治疗剂对目标组织(例如,大脑、脊髓、神经、脑脊液、睾丸、眼球、视网膜、内耳、胎盘、乳腺、肝、胆道、肾、肠、肺、肾上腺皮质、子宫内膜、造血细胞和/或干细胞)的有效输送。