tert-butyl 2-benzyl-2-ethyl-1-methylhydrazinecarboxylate | 1044792-35-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl 2-benzyl-2-ethyl-1-methylhydrazinecarboxylate
• 英文别名: tert-butyl N-[benzyl(ethyl)amino]-N-methylcarbamate
• CAS: 1044792-35-9
• 化学式: C₁₅H₂₄N₂O₂
• 分子量: 264.368
• InChiKey: NTBBKGBAFDUUSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-benzyl-2-ethyl-1-methylhydrazinecarboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以93%的产率得到1-benzyl-1-ethyl-2-methylhydrazine
  参考文献：
  名称：

  Effective strategy for the systematic synthesis of hydrazine derivatives

  摘要：

  A new and efficient strategy for the systematic synthesis of hydrazine derivatives is reported. It allows the synthesis of up to tetrasubstituted hydrazine derivatives with minimal number of steps using only one protecting group or without any of them at all. Simple and readily available starting materials such as hydrazine hydrate or phenylhydrazine can be used. A variety of substrates were used to investigate scope and limitations of this strategy, additionally one full synthetic sequence was performed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.096
• 作为产物：
  描述：

  溴甲苯 、 碘甲烷 、 2-甲基-2-丙基2-乙基肼羧酸酯 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 5.0h， 以60%的产率得到tert-butyl 2-benzyl-2-ethyl-1-methylhydrazinecarboxylate
  参考文献：
  名称：

  Effective strategy for the systematic synthesis of hydrazine derivatives

  摘要：

  A new and efficient strategy for the systematic synthesis of hydrazine derivatives is reported. It allows the synthesis of up to tetrasubstituted hydrazine derivatives with minimal number of steps using only one protecting group or without any of them at all. Simple and readily available starting materials such as hydrazine hydrate or phenylhydrazine can be used. A variety of substrates were used to investigate scope and limitations of this strategy, additionally one full synthetic sequence was performed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.096

文献信息

• Effective strategy for the systematic synthesis of hydrazine derivatives
  作者：Aleksei Bredihhin、Uno Mäeorg

  DOI：10.1016/j.tet.2008.04.096

  日期：2008.7

  A new and efficient strategy for the systematic synthesis of hydrazine derivatives is reported. It allows the synthesis of up to tetrasubstituted hydrazine derivatives with minimal number of steps using only one protecting group or without any of them at all. Simple and readily available starting materials such as hydrazine hydrate or phenylhydrazine can be used. A variety of substrates were used to investigate scope and limitations of this strategy, additionally one full synthetic sequence was performed. (C) 2008 Elsevier Ltd. All rights reserved.