1,1-dimethylethyl(3-formylphenoxy)acetate | 1293050-66-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-dimethylethyl(3-formylphenoxy)acetate
• 英文别名: 2-(3-Formylphenoxy)-2-propylpentanoic acid；2-(3-formylphenoxy)-2-propylpentanoic acid
• CAS: 1293050-66-4
• 化学式: C₁₅H₂₀O₄
• 分子量: 264.321
• InChiKey: MVVXOWAMJVIYQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  哌啶 、 ethyl 4,5-diphenyl-2-oxazoleacetate 、 1,1-dimethylethyl(3-formylphenoxy)acetate 在 对甲苯磺酸 作用下， 以 乙酸乙酯 、 甲苯 为溶剂， 以97%的产率得到(Z)-Ethyl α-[[3-[[(1,1-dimethylethoxy) carbonyl]methoxyl]phenyl]methylene]-4,5-diphenyl-2-oxazoleacetate
  参考文献：
  名称：

  Oxazole carboxylic acid derivatives

  摘要：

  在公式I中披露了一系列噁唑衍生物，其中Y和Z分别为氢或共同形成键；X为CN、CO₂R¹或CO.NR²R³；R和R¹分别或共同为H、Na或C₁-C₅低碳基；R²和R³分别或共同为H或C₁-C₅低碳基；或其碱金属盐。这些化合物可用作抑制ADP诱导的人类富含血小板血浆中的血小板聚集的抑制剂。

  公开号：

  US05187188A1

文献信息

• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577A1

  公开（公告）日：2013-02-20
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• [EN] BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES<br/>[FR] COMPLEXES BIFONCTIONNELS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE TELS COMPLEXES
  申请人：NUEVOLUTION AS

  公开号：WO2011127933A1

  公开（公告）日：2011-10-20

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• Oxazole carboxylic acid derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：US05187188A1

  公开（公告）日：1993-02-16

  A novel series of oxazole derivatives is disclosed in the Formula I ##STR1## wherein Y and Z are independently hydrogen or together form a bond; X is CN, CO.sub.2 R.sup.1 or CO.NR.sup.2 R.sup.3 ; R and R.sup.1 are independently or together H, Na, or C.sub.1 -C.sub.5 lower alkyl; R.sup.2 and R.sup.3 are independently or together H, or C.sub.1 -C.sub.5 lower alkyl; or alkali metal salt thereof. The compounds are useful as inhibitors of ADP-induced blood platelet aggregation in human platelet-rich plasma.

  在公式I中披露了一系列噁唑衍生物，其中Y和Z分别为氢或共同形成键；X为CN、CO₂R¹或CO.NR²R³；R和R¹分别或共同为H、Na或C₁-C₅低碳基；R²和R³分别或共同为H或C₁-C₅低碳基；或其碱金属盐。这些化合物可用作抑制ADP诱导的人类富含血小板血浆中的血小板聚集的抑制剂。