(5E)-5-({5-Bromo-2-[(2-chlorophenyl)methoxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one | 6172-72-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (5E)-5-({5-Bromo-2-[(2-chlorophenyl)methoxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
• 英文别名: (5E)-5-[[5-bromo-2-[(2-chlorophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• CAS: 6172-72-1
• 化学式: C₁₇H₁₁BrClNO₂S₂
• 分子量: 440.8
• InChiKey: KHDGYNGNTRUHKH-OVCLIPMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  95.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Rhodanine Derivatives, a Process for the Preparation Thereof and Pharmaceutical Composition Containing the Same
  申请人：Ryu Seong Eon

  公开号：US20090042872A1

  公开（公告）日：2009-02-12

  Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.

  本文披露了罗丹宁衍生物、其制备方法以及含有相同物质的药物组合物。这些罗丹宁衍生物具有对蛋白磷酸酶（PPase）如PTP1B、Prl-3、LAR、CD45、Cdc25A、Cdc25B、Cdc25C、Yop、PP1和VHR的抑制活性，并可用于预防和治疗PPase引起的疾病，包括自身免疫疾病、糖尿病、糖耐量受损、胰岛素抵抗、肥胖、癌症等，当其抑制活性被调节时。
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  申请人：Lambert Paul F.

  公开号：US20110165220A1

  公开（公告）日：2011-07-07

  A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.
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  公开号：US8148541B2

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  公开号：US9066951B2

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  公开号：US9949980B2

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