1-Adamantyl-(2-hydroxy)acetamid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Adamantyl-(2-hydroxy)acetamid
• 英文别名: 2-(1-adamantyl)-2-hydroxyacetamide
• 化学式: C₁₂H₁₉NO₂
• 分子量: 209.28
• InChiKey: DCFUGCSUWDNDDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] HETEROARYL AMIDE ANALOGUES<br/>[FR] ANALOGUES D'HÉTÉROARYLAMIDES
  申请人：NEUROGEN CORP

  公开号：WO2009023623A1

  公开（公告）日：2009-02-19

  Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib: . In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.

  公开了公式Ia和/或Ib的杂环酰胺类似物的化合物、药物组合物和使用方法。在某些实施例中，这些杂环酰胺类似物是多巴胺受体的激动剂和/或配体，可能有助于治疗对P2X7受体调节敏感的疾病，例如疼痛、炎症、神经系统或神经退行性疾病、心血管疾病、眼部疾病或免疫系统疾病。
• [EN] NOVEL 2-PYRIMIDONE ANALOGS AS POTENT ANTIVIRAL AGENTS AGAINST ALPHAVIRUSES<br/>[FR] NOUVEAUX ANALOGUES DE LA 2-PYRIMIDONE UTILISÉS COMME AGENTS ANTIVIRAUX PUISSANTS CONTRE LES ALPHAVIRUS
  申请人：SOUTHERN RES INST

  公开号：WO2021203048A1

  公开（公告）日：2021-10-07

  The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制病毒感染的2-嘧啶酮化合物以及使用这些化合物治疗病毒感染的方法，例如针对基孔肯雅热、东部马脑炎病毒（EEEV）、西部马脑炎病毒（WEEV）和委内瑞拉马脑炎病毒等的阿尔法病毒感染。本摘要旨在作为特定领域搜索的扫描工具，不限制本发明。
• Heteroaryl Amide Analogues
  申请人：Bakthavatchalam Rajagopal

  公开号：US20120190680A1

  公开（公告）日：2012-07-26

  Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib: In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X 7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.

  本发明揭示了公式Ia和/或Ib的杂环酰胺类似物的化合物、制药组合物和使用方法：在某些实施例中，杂环酰胺类似物是多巴胺受体的激动剂和/或配体，可用于治疗对P2X7受体调节有反应的疾病，例如疼痛、炎症、神经或神经退行性疾病、心血管疾病、眼部疾病或免疫系统疾病等。
• HETEROARYL AMIDE ANALOGUES
  申请人：H. Lundbeck A/S

  公开号：EP2185560A1

  公开（公告）日：2010-05-19
• [EN] CO-CRYSTALLINE FORMS OF CARBAMAZEPINE<br/>[FR] FORMES CO-CRISTALLINES DE CARBAMAZÉPINE
  申请人：AVANTIUM HOLDING B V

  公开号：WO2008108639A1

  公开（公告）日：2008-09-12

  [EN] The present invention provides a novel crystalline form of a cocrystal of carbamazepine : glycolamide and of a co-crystal of carbamazepine : lactamide. The invention further provides methods for the preparation of a co-crystal of carbamazepine: glycolamide and and/or carbamazepine : lactamide, as well as their use in pharmaceutical applications, in particular in medicaments for he treatment of epilepsy, bipolar disorder, schizophrenia and/or trigeminal neuralgia. The co-crystalline form of carbamazepine: glycolamide and/ or carbamazepine : lactamide can be used in combination with other medicaments.
  [FR] La présente invention concerne une forme co-cristalline atypique d'un co-cristal de carbamazépine : glycolamide et d'un co-cristal de carbamazépine : lactamide. L'invention concerne en outre des procédés pour la préparation d'un co-cristal de carbamazépine : glycolamide et/ou de carbamazépine : lactamide, ainsi que leur utilisation dans des applications pharmaceutiques, en particulier dans des médicaments pour le traitement de l'épilepsie, du trouble bipolaire, de la schizophrénie et/ou de la névralgie faciale. La forme co-cristalline de carbamazépine : glycolamide et/ou de carbamazépine : lactamide peut être utilisée en combinaison avec d'autres médicaments.