(2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide
• 化学式: C35H42ClN5O9S
• 分子量: 744.3
• InChiKey: OJZLFDUERKXFGR-UVJOBNTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.16
• 重原子数：
  51
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  251
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• Fixed Dosage Formulations of Angiotensin Converting Enzyme (ACE) inhibitor and the Diuretic Chlorthalidone
  申请人：Rajan Dorai T.

  公开号：US20150272930A1

  公开（公告）日：2015-10-01

  The invention describes fixed dosage formulations of an angiotensin converting enzyme (ACE) inhibitor, preferably Lisinopril and the diuretic, preferably Chlorthalidone in the same pharmaceutically acceptable carrier, for example a tablet, capsule or oral suspension and methods of treating hypertension by administering the fixed dosage formulation of Lisinopril and Chlorthalidone to a patient in need thereof.
• [EN] FIIXED DOSAGE FORMULATIONS OF ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITOR AND THE DIURETIC CHLORTHALIDONE<br/>[FR] FORMULATIONS DE POSOLOGIE FIXE D'INHIBITEUR D'ENZYME DE CONVERSION DE L'ANGIOTENSINE (ACE) ET DE CHLORTHALIDONE DIURÉTIQUE
  申请人：AILEX PHARMACEUTICALS PVT LTD

  公开号：WO2015153379A1

  公开（公告）日：2015-10-08

  The invention describes fixed dosage formulations of an angiotensin converting enzyme (ACE) inhibitor, preferably Lisinopril and the diuretic, preferably Chlorthalidone in the same pharmaceutically acceptable carrier, for example a tablet, capsule or oral suspension and methods of treating hypertension by administering the fixed dosage formulation of Lisinopril and Chlorthalidone to a patient in need thereof.