(R)-3-hydroxy-3-methyl-2-oxopentanoic acid | 17125-32-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: (R)-3-hydroxy-3-methyl-2-oxopentanoic acid
• 英文别名: (3R)-3-hydroxy-3-methyl-2-oxopentanoic acid
• CAS: 17125-32-5
• 化学式: C₆H₁₀O₄
• 分子量: 146.143
• InChiKey: YJVOWRAWFXRESP-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2R,3R)-2,3-dihydroxy-3-methylpetanoic acid 、 3-羟基-3-甲基-2-氧代丁酸 在 αβ-dihydroxyacid dehydratase EC 4.2.1.9 of Salmonella typhimurium 作用下， 生成 (R)-3-hydroxy-3-methyl-2-oxopentanoic acid
  参考文献：
  名称：

  Armstrong, Frank B.; Lipscomb, Elizabeth L.; Crout, David H. G., Journal of the Chemical Society. Perkin transactions I, 1985, p. 691 - 696

  摘要：

  DOI：

文献信息

• [EN] CELL-FREE SYNTHESIS OF ISOTOPIC LABELLED PROTEINS FROM AMINO-ACIDS PRECURSORS<br/>[FR] SYNTHÈSE ACELLULAIRE DE PROTÉINES MARQUÉES ISOTOPIQUES À PARTIR DE PRÉCURSEURS D'ACIDES AMINÉS
  申请人：NMR BIO

  公开号：WO2018157942A1

  公开（公告）日：2018-09-07

  Process of cell-free synthesis of a target protein, comprising at least the following steps: a. providing at least one precursor of an amino-acid, a cell-free extract comprising means for transforming said precursor of an amino-acid into the corresponding amino-acid, at least one tRNA for integrating said amino-acid into the corresponding target protein, in which the at least one precursor of amino-acid is an alpha-keto acid, with the proviso that 2-ketobutyric acid is excluded, b. mixing the compounds provided in step a) to obtain a mixture, c. adding to said mixture obtained in step b) a DNA or a mRNA coding to said target protein in order to produce said target protein.
• Armstrong, Frank B.; Lipscomb, Elizabeth L.; Crout, David H. G., Journal of the Chemical Society. Perkin transactions I, 1985, p. 691 - 696
  作者：Armstrong, Frank B.、Lipscomb, Elizabeth L.、Crout, David H. G.、Morgan, Phillip J.

  DOI：——

  日期：——