(2R:3S:6R)-3,4-dimethyl-2-phenyl-6-(tosylmethyl)morpholine | 136908-45-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (2R:3S:6R)-3,4-dimethyl-2-phenyl-6-(tosylmethyl)morpholine
• 英文别名: (2R,3S,6R)-3,4-dimethyl-6-[(4-methylphenyl)sulfonylmethyl]-2-phenylmorpholine
• CAS: 136908-45-7
• 化学式: C₂₀H₂₅NO₃S
• 分子量: 359.489
• InChiKey: AKWWVWWIEALSML-HQRMLTQVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.23
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.61
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1-甲基-4-丙-2-烯基磺酰基苯 在 溴 作用下， 以 四氯化碳 、 二氯甲烷 为溶剂， 反应 28.0h， 生成 (2R:3S:6R)-3,4-dimethyl-2-phenyl-6-(tosylmethyl)morpholine
  参考文献：
  名称：

  A simple method for the synthesis of γ-functionalized vinyl and allyl sulfones

  摘要：

  The synthesis of gamma-functionalized vinyl sulfones 3 have been carried out directly starting from dibromides 2 derived from allyl sulfones 1 by reaction with different nucleophiles. The process is stereoselective affording compounds 3 with E configuration except in the case of methallylic derivatives. The regioisomeric gamma-functionalized allyl sulfones 4 were obtained from dibromides 2 or from vinyl sulfones 3, with Z configuration, except when triphenylphosphine was used as nucleophile, in this case the corresponding (E)-vinylphosphonium bromide 4al was obtained.

  DOI：

  10.1016/s0040-4020(01)86563-7

文献信息

• A simple method for the synthesis of γ-functionalized vinyl and allyl sulfones
  作者：Carmen Nájera、Alfonso Pérez-Pinar、JoséM. Sansano

  DOI：10.1016/s0040-4020(01)86563-7

  日期：1991.8

  The synthesis of gamma-functionalized vinyl sulfones 3 have been carried out directly starting from dibromides 2 derived from allyl sulfones 1 by reaction with different nucleophiles. The process is stereoselective affording compounds 3 with E configuration except in the case of methallylic derivatives. The regioisomeric gamma-functionalized allyl sulfones 4 were obtained from dibromides 2 or from vinyl sulfones 3, with Z configuration, except when triphenylphosphine was used as nucleophile, in this case the corresponding (E)-vinylphosphonium bromide 4al was obtained.