(4-Azaniumyl-5-methoxy-5-oxopentyl)-(diaminomethylidene)azanium;dichloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4-Azaniumyl-5-methoxy-5-oxopentyl)-(diaminomethylidene)azanium;dichloride
• 英文别名: (4-azaniumyl-5-methoxy-5-oxopentyl)-(diaminomethylidene)azanium;dichloride
• 化学式: C7H18Cl2N4O2
• 分子量: 261.15
• InChiKey: XQYZOBNLCUAXLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.23
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  117
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Method for modifying protein or peptide C-terminal
  申请人：Nakazawa Takashi

  公开号：US20050085622A1

  公开（公告）日：2005-04-21

  A simple and low-cost method of selectively modifying the C-terminal of a protein or peptide is provided. A method of modifying the C-terminal of a protein or peptide comprises forming an intramolecular oxazolone ring at the C-terminal of the protein or peptide that requires C-terminal modification, and then performing a ring-opening of the oxazolone ring to produce a protein or peptide with a modified C-terminal. Preferred forms include a method in which by reacting the oxazolone ring with a compound containing a nucleophilic group to effect an oxazolone ring-opening, a protein or peptide is produced in which the C-terminal is modified with the compound containing the nucleophilic group, as well as a method in which by reacting the oxazolone ring with an active esterifying agent to effect a ring-opening, the oxazolone is converted to an active ester, which by subsequent reaction with a compound containing a nucleophilic group, produces a protein or peptide in which the C-terminal has been modified with the compound containing the nucleophilic group.

  本研究提供了一种选择性修饰蛋白质或肽的 C-末端的简单而低成本的方法。修饰蛋白质或肽的 C 端的方法包括在需要进行 C 端修饰的蛋白质或肽的 C 端形成分子内恶唑酮环，然后对恶唑酮环进行开环反应，生成具有修饰 C 端的蛋白质或肽。优选的形式包括这样一种方法：通过使噁唑酮环与含有亲核基团的化合物反应以实现噁唑酮环开环，从而制备出一种蛋白质或肽，其中的 C-末端被含有亲核基团的化合物修饰、以及一种方法，在该方法中，通过使噁唑酮环与活性酯化剂反应以实现开环，噁唑酮被转化为活性酯，通过随后与含有亲核基团的化合物反应，产生一种蛋白质或肽，在该蛋白质或肽中，C-末端被含有亲核基团的化合物修饰。
• NOVEL LIPOPHILIC COMPOSITIONS AND USES THEREOF
  申请人：Clement Jean-Claude

  公开号：US20110008415A1

  公开（公告）日：2011-01-13

  New co-lipids for use in combination with lipophilic compounds as nucleic acid vectors, for preparing a nucleic acid vector composition, and methods for introducing in vitro or in vivo a nucleic acid of interest into host cells, including a step of contacting host cells these nucleic acid vector compositions. The nucleic acid vector compositions have the combination (i) of a nucleic acid, cationic, lipophilic vector with (ii) a co-lipid. These nucleic acid vector compositions, in some embodiments, are present in the form of unilamellar or multilamellar vesicles.
• US5202416A
  申请人：——

  公开号：US5202416A

  公开（公告）日：1993-04-13
• US7294707B2
  申请人：——

  公开号：US7294707B2

  公开（公告）日：2007-11-13
• [EN] IMPROVEMENTS IN ENZYME STABILITY<br/>[FR] AMELIORATIONS DE LA STABILITE DES ENZYMES
  申请人：UNISEARCH LTD

  公开号：WO2002098824A2

  公开（公告）日：2002-12-12

  An enzyme for cleaving β-1,4 -glucosidic bonds of cellulose comprising a cellulase having an aromatic group linked to a side chain of an amino acid residue or to a terminal amino acid residue of the cellulase wherein the enzyme functions at an elevated temperature and/or has an extended half-life at elevated temperature compared to the corresponding unmodified cellulose.

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