3-Morpholin-4-ylpropylsulfonyl 3-morpholin-4-ylpropane-1-sulfonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 3-Morpholin-4-ylpropylsulfonyl 3-morpholin-4-ylpropane-1-sulfonate
• 英文别名: 3-morpholin-4-ylpropylsulfonyl 3-morpholin-4-ylpropane-1-sulfonate
• 化学式: C₁₄H₂₈N₂O₇S₂
• 分子量: 400.5
• InChiKey: GWLMHFBTZUMVJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  119
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• ß-LACTAMASE INHIBITOR AND USE THEREOF
  申请人：Suzhou Sinovent Pharmaceuticals Co., Ltd.

  公开号：EP3744722A1

  公开（公告）日：2020-12-02

  Provided are a β-lactamase inhibitor of formula (I), or an ester, a stereoisomer or a pharmaceutically acceptable salt thereof, and a method of preparing the same. Further provided is a pharmaceutical composition comprising the β-lactamase inhibitor of formula (I), or the ester, the stereoisomer or pharmaceutically acceptable salt thereof. In addition, the present invention relates to a method for treating diseases caused by bacterial infection, which comprises administering the β-lactamase inhibitor of formula (I), or the ester, the stereoisomer or the pharmaceutically acceptable salt thereof to a patient or a subject in need.

  提供了一种式（I）的β-内酰胺酶抑制剂，或其酯、立体异构体或药学上可接受的盐，以及制备方法。本发明还提供了一种药物组合物，其中包含式（I）的β-内酰胺酶抑制剂或其酯、立体异构体或药学上可接受的盐。此外，本发明还涉及一种治疗由细菌感染引起的疾病的方法，该方法包括向患者或有需要的受试者施用式（I）的β-内酰胺酶抑制剂或其酯、立体异构体或药学上可接受的盐。
• β-lactamase inhibitor and use thereof
  申请人：SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.

  公开号：US11078202B2

  公开（公告）日：2021-08-03

  Provided are a β-lactamase inhibitor of formula (I), or an ester, a stereoisomer or a pharmaceutically acceptable salt thereof, and a method of preparing the same. Further provided is a pharmaceutical composition comprising the β-lactamase inhibitor of formula (I), or the ester, the stereoisomer or pharmaceutically acceptable salt thereof. In addition, the present invention relates to a method for treating diseases caused by bacterial infection, which comprises administering the β-lactamase inhibitor of formula (I), or the ester, the stereoisomer or the pharmaceutically acceptable salt thereof to a patient or a subject in need.

  提供了一种式（I）的β-内酰胺酶抑制剂，或其酯、立体异构体或药学上可接受的盐，以及制备方法。本发明还提供了一种药物组合物，其中包含式（I）的β-内酰胺酶抑制剂或其酯、立体异构体或药学上可接受的盐。此外，本发明还涉及一种治疗由细菌感染引起的疾病的方法，该方法包括向患者或有需要的受试者施用式（I）的β-内酰胺酶抑制剂或其酯、立体异构体或药学上可接受的盐。
• Beta-lactamase inhibitor and use thereof
  申请人：SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.

  公开号：US20210046057A1

  公开（公告）日：2021-02-18

  Provided are a β-lactamase inhibitor of formula (I), or an ester, a stereoisomer or a pharmaceutically acceptable salt thereof, and a method of preparing the same. Further provided is a pharmaceutical composition comprising the β-lactamase inhibitor of formula (I), or the ester, the stereoisomer or pharmaceutically acceptable salt thereof. In addition, the present invention relates to a method for treating diseases caused by bacterial infection, which comprises administering the β-lactamase inhibitor of formula (I), or the ester, the stereoisomer or the pharmaceutically acceptable salt thereof to a patient or a subject in need.