(2,2-diphenylethyl)carbamoyl azide | 1010414-77-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,2-diphenylethyl)carbamoyl azide
• 英文别名: 1-Diazo-3-(2,2-diphenylethyl)urea；1-diazo-3-(2,2-diphenylethyl)urea
• CAS: 1010414-77-3
• 化学式: C₁₅H₁₄N₄O
• 分子量: 266.302
• InChiKey: CARRGADNUOYUAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  43.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2,2-diphenylethyl)carbamoyl azide 、 二乙胺 生成 3-(2,2-diphenylethyl)-1,1-diethylurea
  参考文献：
  名称：

  Controlled conversion of phenylacetic acids to phenylacetonitriles or benzonitriles using bis(2-methoxyethyl)aminosulfur trifluoride

  摘要：

  A mild, efficient, and practical method for the one-step synthesis of benzonitriles from phenylacetic acids using bis(2-methoxyethyl)aminosulfur trifluoride is described. The reaction was easily extended to the synthesis of the corresponding phenylacetonitriles by inclusion of triethylphosphine. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.090
• 作为产物：
  描述：

  3,3-二苯基丙酸 在 sodium azide 、 N,N-二异丙基乙胺 、 [双(2-甲氧基乙基)胺]三氟化硫 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 1.0h， 以92%的产率得到(2,2-diphenylethyl)carbamoyl azide
  参考文献：
  名称：

  Controlled conversion of phenylacetic acids to phenylacetonitriles or benzonitriles using bis(2-methoxyethyl)aminosulfur trifluoride

  摘要：

  A mild, efficient, and practical method for the one-step synthesis of benzonitriles from phenylacetic acids using bis(2-methoxyethyl)aminosulfur trifluoride is described. The reaction was easily extended to the synthesis of the corresponding phenylacetonitriles by inclusion of triethylphosphine. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.090

文献信息

• Controlled conversion of phenylacetic acids to phenylacetonitriles or benzonitriles using bis(2-methoxyethyl)aminosulfur trifluoride
  作者：Cyrous O. Kangani、Billy W. Day、David E. Kelley

  DOI：10.1016/j.tetlet.2007.11.090

  日期：2008.1

  A mild, efficient, and practical method for the one-step synthesis of benzonitriles from phenylacetic acids using bis(2-methoxyethyl)aminosulfur trifluoride is described. The reaction was easily extended to the synthesis of the corresponding phenylacetonitriles by inclusion of triethylphosphine. (C) 2007 Elsevier Ltd. All rights reserved.