Prop-2-enyl 2-amino-3-(4-hydroxyphenyl)propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Prop-2-enyl 2-amino-3-(4-hydroxyphenyl)propanoate
• 化学式: C₁₂H₁₅NO₃
• 分子量: 221.25
• InChiKey: CEVOYCWAYIDADP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Rheology control agents
  申请人：Lenges Peter Christian

  公开号：US20060155146A1

  公开（公告）日：2006-07-13

  The present invention provides for a rheology control agent that includes a following compound represented by the following formula: wherein A, B, C and D equal CH 2 , CHR, NH, or O, and A, B, C and D may be the same or different and at least one of A and B equals NH and at least one of C and D equals NH; and wherein R 1 , R 2 , and R 3 may be the same or different and represent a linear, branched, hyper-branched, or dendritic ether, polyether or hydrocarbon based chain, optionally forming at least one carbon-based ring, being saturated or unsaturated and R 2 represents linear or branched alkylenes, ethers, polyethers, or polyester linkages and at least one of R 1 , R 2 , and R 3 comprises an ester group or an amide group which is branched off from the main chain; excluded from Formula (1) is a compound wherein R 2 is CH 2 —CH 2 —CH 2 —CH 2 —CH(C(O)OCH 3 ), A, B, C, and D are equal to NH and R 1 and R 3 are both equal to a linear octyl hydrocarbon chain; the rheology control agent is suitable for solvent-borne and water-borne coating composition having improved rheology control useful for OEM refinishing or repainting the exterior of automobile and truck bodies and parts thereof.

  本发明提供了一种流变控制剂，包括下式所示的化合物：其中A、B、C和D等于CH2、CHR、NH或O，A、B、C和D可以相同也可以不同，且至少有一个A和B等于NH，至少有一个C和D等于NH；R1、R2和R3可以相同也可以不同，表示线性、支链、超支链或树枝状醚、聚醚或碳氢基链，可选地形成至少一个碳基环，饱和或不饱和，其中R2表示线性或支链烷基、醚、聚醚或聚酯键合，且R1、R2和R3中至少有一个包括从主链上分支出的酯基或酰胺基；式（1）中不包括R2为 — — — —CH(C(O)OCH3)、A、B、C和D均等于NH，且R1和R3均等于线性辛基碳氢链的化合物；该流变控制剂适用于改善流变控制的溶剂型和水性涂料组合物，可用于汽车和卡车车身及其零部件的OEM翻新或重新涂装。
• BIORESORBABLE POLYMERS SYNTHESIZED FROM MONOMER ANALOGS OF NATURAL METABOLITES
  申请人：Kohn Joachim B.

  公开号：US20110275782A1

  公开（公告）日：2011-11-10

  New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles

  新的可降解生物聚合物是从天然代谢产物的单体类似物合成的。特别是，这些聚合物是从氨基酸的类似物聚合而成的，这些氨基酸有助于为所制备的聚合物提供有利的合成、加工和材料特性，包括特别有利的降解特性。
• [EN] SYNTHESIS OF TYROSINE DERIVED DIPHENOL MONOMERS<br/>[FR] SYNTHÈSE DE MONOMÈRES DE DIPHÉNOL DÉRIVÉS DE TYROSINE
  申请人：TYRX INC

  公开号：WO2018226340A1

  公开（公告）日：2018-12-13

  A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution, EDCI HCI is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.

  一种制备二酚化合物的方法，包括加入羟基苯甲酸、酪氨酸乙酯、羟基苯并三唑水合物和溶剂，并搅拌以产生第一溶液，向第一溶液中加入EDCI HCI以产生第一混合物。将乙酸乙酯加入第一混合物以产生第二混合物。将第二混合物加入氯化钠中以产生具有层分离的第三混合物。从第三混合物中除去水层。在从第三混合物中除去水层后，用试剂提取第三混合物以产生第四混合物。将硫酸镁加入第四混合物中以产生第五混合物。将第五混合物过滤以产生滤液。浓缩滤液并诱导结晶。向结晶的滤液中加入二氯甲烷以产生固体产物。
• [EN] CYCLIC PEPTIDE INHIBITORS OF HEDGEHOG PROTEINS<br/>[FR] INHIBITEURS PEPTIDIQUES CYCLIQUES DE PROTÉINES HEDGEHOG
  申请人：UNIV ROCHESTER

  公开号：WO2017223207A1

  公开（公告）日：2017-12-28

  Cyclic peptide compounds are provided that can bind to one or more homologs of Hedghehog signaling proteins and block their interaction with the Patched receptor. These compounds are useful for suppressing Hedgehog-dependent stimulation of the Hedgehog pathway in cells and in living organisms. Methods for using the cyclic peptide compounds, and compositions comprising them, for treatment of cancers and other diseases which are characterized by aberrant Hedgehog-dependent activation of the Hedgehog pathway and/or which can benefit from chemical suppression of Hedgehog-dependent signaling are also disclosed.

  本发明提供了可以结合一个或多个Hedghehog信号蛋白同源物并阻止它们与Patched受体相互作用的环肽化合物。这些化合物对于抑制细胞和生物体中Hedgehog通路的Hedgehog依赖性刺激非常有用。还公开了使用环肽化合物的方法和包含它们的组合物，用于治疗癌症和其他疾病，这些疾病的特征是Hedgehog通路的异常Hedgehog依赖性激活和/或可以受益于化学抑制Hedgehog依赖性信号。
• Radio-opaque polymeric biomaterials
  申请人：Rutgers, The State University

  公开号：EP1702914A1

  公开（公告）日：2006-09-20

  The present invention relates to an implantable radio-opaque medical device comprising a radio-opaque, iodine- or bromine-substituted polymer, characterized by at least one repeating unit described by the formula:

  本发明涉及一种植入式不透射线医疗器械，它由一种不透射线的碘或溴取代聚合物组成，其特征在于至少有一个重复单元按式描述：