1,2-Dimethylbutane-1,2,3-tricarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,2-Dimethylbutane-1,2,3-tricarboxylic acid
• 英文别名: 1,2-dimethylbutane-1,2,3-tricarboxylic acid
• 化学式: C₉H₁₄O₆
• 分子量: 218.2
• InChiKey: DMKJEUKXQNNFFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Methods of reducing or eliminating tooth staining by application of stain barrier films
  申请人：Hegemon Enterprises, LLC

  公开号：US10376458B2

  公开（公告）日：2019-08-13

  The invention includes methods for reducing or preventing the staining capacity of a compound to a tooth in a mammalian oral cavity, which includes affixing to the tooth surface a degradable film. The film comprises a starch polymer or copolymer that is formed by crosslinking a starch. The film degrades in the oral cavity within about 1 minute to about 70 minutes after affixation. In some embodiments, it may be preferred the crosslinking occurs in the presence of at least one (poly)carboxylic acid. It may be preferred that the starch selected is a retrograde starch, a starch that is chemically or physically modified to be amylase resistant or a starch that is derived naturally but exhibits amylase resistance.

  本发明包括降低或防止化合物对哺乳动物口腔中的牙齿染色能力的方法，其中包括在牙齿表面粘贴一层可降解薄膜。薄膜由淀粉聚合物或共聚物组成，淀粉聚合物或共聚物是通过淀粉交联形成的。粘贴后，薄膜会在口腔内约 1 分钟至约 70 分钟内降解。在某些实施方案中，交联最好在至少有一种（聚）羧酸存在的情况下进行。所选淀粉最好是逆淀粉、经化学或物理改性后具有抗淀粉酶性的淀粉或天然提取但具有抗淀粉酶性的淀粉。
• Methods of Reducing or Eliminating Tooth Staining By Application of Stain Barrier Films
  申请人：Hegemon Enterprises, LLC

  公开号：US20160000684A1

  公开（公告）日：2016-01-07

  The invention includes methods for reducing or preventing the staining capacity of a compound to a tooth in a mammalian oral cavity, which includes affixing to the tooth surface a degradable film. The film comprises a starch polymer or copolymer that is formed by crosslinking a starch. The film degrades in the oral cavity within about 1 minute to about 70 minutes after affixation. In some embodiments, it may be preferred the crosslinking occurs in the presence of at least one (poly)carboxylic acid. It may be preferred that the starch selected is a retrograde starch, a starch that is chemically or physically modified to be amylase resistant or a starch that is derived naturally but exhibits amylase resistance.