(1R,2S,3R,4S)-2-Benzoylamino-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-methyl ester | 178232-11-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1R,2S,3R,4S)-2-Benzoylamino-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-methyl ester
• 英文别名: (1S,2R,3S,4R)-3-Benzamido-3-methoxycarbonylbicyclo[2.2.1]heptane-2-carboxylic acid；(1S,2R,3S,4R)-3-benzamido-3-methoxycarbonylbicyclo[2.2.1]heptane-2-carboxylic acid
• CAS: 178232-11-6
• 化学式: C₁₇H₁₉NO₅
• 分子量: 317.342
• InChiKey: GOCYYKVWHKVGFJ-LKQDWFRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (1R,2S,3R,4S)-2-Benzoylamino-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-methyl ester 在 盐酸 作用下， 反应 48.0h， 以80%的产率得到(1R,2S,3R,4S)-2-Amino-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid; hydrochloride
  参考文献：
  名称：

  Diastereoselective synthesis of (1S,2S,3R,4R) and (1R,2S,3R,4S)-bicyclo[2.2.1]hept-2-amino-2,3-dicarboxylic acids: New conformationally-constrained (S)-aspartic acid analogues

  摘要：

  The title compounds were prepared from key intermediates readily obtained by the stereoselective Diels-Alder reaction of (Z)-2-phenyl-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-ylmethylene]-5(4H)-oxazolone, a chiral az-lactone derived from (R)-glyceraldehyde and cyclopentadiene. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00172-3
• 作为产物：
  描述：

  (1S,2S,3R,4R)-2-Benzoylamino-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester 在 palladium on activated charcoal 盐酸 、 ruthenium trichloride 、 sodium periodate 、 氢气 作用下， 以 甲醇 、 四氯化碳 、 乙酸乙酯 、 乙腈 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 52.0h， 生成 (1R,2S,3R,4S)-2-Benzoylamino-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-methyl ester
  参考文献：
  名称：

  Diastereoselective synthesis of (1S,2S,3R,4R) and (1R,2S,3R,4S)-bicyclo[2.2.1]hept-2-amino-2,3-dicarboxylic acids: New conformationally-constrained (S)-aspartic acid analogues

  摘要：

  The title compounds were prepared from key intermediates readily obtained by the stereoselective Diels-Alder reaction of (Z)-2-phenyl-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-ylmethylene]-5(4H)-oxazolone, a chiral az-lactone derived from (R)-glyceraldehyde and cyclopentadiene. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00172-3

文献信息

• Diastereoselective synthesis of (1S,2S,3R,4R) and (1R,2S,3R,4S)-bicyclo[2.2.1]hept-2-amino-2,3-dicarboxylic acids: New conformationally-constrained (S)-aspartic acid analogues
  作者：Elena Buñuel、Carlos Cativiela、Maria D. Diaz-de-Villegas

  DOI：10.1016/0957-4166(96)00172-3

  日期：1996.5

  The title compounds were prepared from key intermediates readily obtained by the stereoselective Diels-Alder reaction of (Z)-2-phenyl-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-ylmethylene]-5(4H)-oxazolone, a chiral az-lactone derived from (R)-glyceraldehyde and cyclopentadiene. Copyright (C) 1996 Elsevier Science Ltd