Bipyridinkalium | 80481-15-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Bipyridinkalium
• 英文别名: Potassium (2,2'-bipyridine)
• CAS: 80481-15-8
• 化学式: C₁₀H₈KN₂
• 分子量: 195.285
• InChiKey: PYEOQYNEUXLUSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.76
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Bipyridinkalium 、 diphenyl beryllium 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Kaim, Wolfgang, Chemische Berichte, 1981, vol. 114, # 12, p. 3789 - 3800

  摘要：

  DOI：

文献信息

• Use of phosphotyrosine phosphatase inhibitors or phosphotyrosine kinase
  申请人：Bristol-Myers Squibb Company

  公开号：US05846998A1

  公开（公告）日：1998-12-08

  A method of inhibiting the proliferation of B cells by using inhibitors of phosphotyrosine phosphatase can be used to regulate the immune response and to treat diseases such as leukemias or lymphomas marked by malignant proliferation of B cells or T cells. Antitumor activity is seen in vivo against tumors and against tumor cell lines. The use o such inhibitors can be combined with radiation, which produces a synergistic effect. Several types of inhibitors can be used, including: (1) compounds comprising a metal coordinate-covalently bound to an organic moiety that can form a five- or six-membered ring, in which the metal is preferably vanadium (IV); (2) compounds in which vanadium (IV) is coordinate-covalently bound to an organic moiety such as a hydroxamate, .alpha.-hydroxypyridinone, .alpha.-hydroxypyrone, .alpha.-amino acid, hydroxycarbonyl, or thiohydroxamate; (3) coordinate-covalent complexes of cysteine or a derivative thereof; (4) nonhydrolyzable phosphotyrosine analogues; (5) dephostatin; (6) 4-(fluoromethyl)phenyl phosphate and esterified derivatives; and (7) coordinate-covalent metal-organic compounds containing at least one oxo or peroxo ligand bound to the metal, in which the metal is preferably vanadium (V), molybdenum (VI), or tungsten (VI).

  使用磷酸酪氨酸酶抑制剂抑制B细胞增殖的方法可用于调节免疫反应并治疗由B细胞或T细胞恶性增殖标记的白血病或淋巴瘤等疾病。在体内观察到对肿瘤和肿瘤细胞系的抗肿瘤活性。这些抑制剂的使用可以与放射线结合使用，产生协同作用。可以使用几种类型的抑制剂，包括：（1）包含金属配位共价结合到可以形成五元或六元环的有机基团的化合物，其中金属最好是钒（IV）；（2）钒（IV）与羟肟酸，α-羟基吡啶酮，α-羟基吡酮，α-氨基酸，羟基羰基或硫羟肟酸等有机基团共价结合的化合物；（3）半胱氨酸或其衍生物的配位共价络合物；（4）不可水解的磷酸酪氨酸类似物；（5）去磷酸酯酶；（6）4-（氟甲基）苯磷酸和酯化衍生物；（7）含有至少一个氧或过氧配体与金属结合的配位共价金属-有机化合物，其中金属最好是钒（V），钼（VI）或钨（VI）。
• Phosphotyrosine phosphatase inhibitors or phosphotyrosine kinase
  申请人：Bristol-Myers Squibb Company

  公开号：US05877210A1

  公开（公告）日：1999-03-02

  A method of inhibiting the proliferation of B cells by using inhibitors of phosphotyrosine phosphatase can be used to regulate the immune response and to treat diseases such as leukemias or lymphomas marked by malignant proliferation of B cells or T cells. Antitumor activity is seen in vivo against tumors and against tumor cell lines. The use of such inhibitors can be combined with radiation, which produces a synergistic effect. Several types of inhibitors can be used, including: (1) compounds comprising a metal coordinate-covalently bound to an organic moiety that can form a five- or six-membered ring, in which the metal is preferably vanadium (IV); (2) compounds in which vanadium (IV) is coordinate-covalently bound to an organic moiety such as a hydroxamate, .alpha.-hydroxypyridinone, .alpha.-hydroxypyrone, .alpha.-amino acid, hydroxycarbonyl, or thiohydroxamate; (3) coordinate-covalent complexes of vanadyl and cysteine or a derivative thereof; (4) nonhydrolyzable phosphotyrosine phosphatase analogues; (5) dephostatin; (6) 4-(fluoromethyl)phenyl phosphate and esterified derivatives; and (7) coordinate-covalent metal-organic compounds containing at least one oxo or peroxo ligand bound to the metal, in which the metal is preferably vanadium (V), molybdenum (VI), or tungsten (VI). Methods of stimulating signaling in T cells and conjugates of a modulator of phosphotyrosine metabolism with a specific binding partner for a B cell surface antigen are also disclosed.

  一种通过使用磷酸酪氨酸磷酸酶抑制剂来抑制B细胞增殖的方法可用于调节免疫反应并治疗白血病或淋巴瘤等由B细胞或T细胞恶性增殖标记的疾病。在体内对肿瘤和肿瘤细胞系显示出抗肿瘤活性。这种抑制剂的使用可以与放射线结合使用，产生协同作用。可以使用多种类型的抑制剂，包括：（1）化合物，包括金属配位共价结合到可以形成五元或六元环的有机基团中，其中金属优选为钒（IV）；（2）化合物，其中钒（IV）与羟肟酸酯、α-羟基吡啶酮、α-羟基吡酮、α-氨基酸、羟基羰基或硫羟肟等有机基团共价配位结合；（3）钒酰和半胱氨酸或其衍生物的配位共价络合物；（4）不可水解的磷酸酪氨酸磷酸酶类似物；（5）去磷酸酪氨酸酶；（6）4-（氟甲基）苯磷酸和酯化衍生物；以及（7）含有至少一个氧或过氧配体结合到金属的配位共价金属有机化合物，其中金属优选为钒（V）、钼（VI）或钨（VI）。还公开了刺激T细胞信号传导的方法和磷酸酪氨酸代谢调节剂与特定结合伴侣结合到B细胞表面抗原的共轭物。
• Tris(carbene)borates; alternatives to cyclopentadienyls in organolanthanide chemistry
  作者：Amy N. Price、Ankur K. Gupta、Wibe A. de Jong、Polly L. Arnold

  DOI：10.1039/d3dt00718a

  日期：——

  The chemistry of the tris-carbene anion phenyltris(3-alkyl-imidazoline-2-yliden-1-yl)borate, [C3Me]− ligand, is initiated for f-block metal cations. Neutral, molecular complexes of the form Ln(C3)2I are formed for cerium(III), while a separated ion pair [Ln(C3)2]I forms for ytterbium(III). DFT/QTAIM computational analyses of the complexes and related tridentate tris(pyrazolyl)borate (Tp) – supported

  三卡宾阴离子苯基三(3-烷基-咪唑啉-2-亚基-1-基)硼酸盐， [C3 Me ] -配体的化学反应是由f-嵌段金属阳离子引发的。铈( III ) 形成Ln(C3) 2 I形式的中性分子配合物，而镱( III ) 则形成分离的离子对[Ln(C3) 2 ]I 。对配合物和相关三齿三(吡唑基)硼酸盐 ( Tp ) 支持的类似物的 DFT/QTAIM 计算分析证明了 σ 供体的预期强度，并证实了相比之下[C3 Me ] -配合物的金属-碳键具有更大的共价性与那些在Tp Me,Me复合体中的人。 DFT 计算证明了 THF 溶剂在准确再现 Ce 和 Yb 配合物实验观察到的对比分子和离子对几何形状方面的关键作用。