4-[(E)-(1-methyl-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl]benzoic acid | 5809-84-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-[(E)-(1-methyl-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl]benzoic acid
• 英文别名: 4-[(E)-(1-methyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]benzoic acid
• CAS: 5809-84-7
• 化学式: C₁₃H₁₀N₂O₅
• 分子量: 274.23
• InChiKey: FOCATHRHRUAECA-RMKNXTFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHODS AND COMPOSITIONS FOR TARGETING C-REL
  申请人：Cornell Research Foundation, Inc.

  公开号：EP2010225A2

  公开（公告）日：2009-01-07
• Methods and Compositions for Targeting c-Rel
  申请人：Liou Hsiou-chi

  公开号：US20100055116A1

  公开（公告）日：2010-03-04

  The present invention relates to compositions and methods for targeting c-Rel. In particular, the present invention provides compositions and methods for treating cancers, inflammatory diseases, autoimmune diseases, and transplant rejection by inhibiting c-Rel activity and for regulating c-Rel for research and drug screening applications.
• [EN] METHODS AND COMPOSITIONS FOR TARGETING C-REL<br/>[FR] PROCEDES ET COMPOSITIONS DESTINES A CIBLER LE C-REL
  申请人：CORNELL RES FOUNDATION INC

  公开号：WO2007120842A2

  公开（公告）日：2007-10-25

  [EN] The present invention relates to compositions and methods for targeting c-Rel. In particular, the present invention provides compositions and methods for treating cancers, inflammatory diseases, autoimmune diseases, and transplant rejection by inhibiting c-Rel activity and for regulating c-Rel for research and drug screening applications.
  [FR] La présente invention concerne des compositions et des procédés destinés à cibler le c-Rel. L'invention porte en particulier sur des compositions et des procédés permettant de traiter les cancers, les maladies inflammatoires, les maladies auto-immunes et les rejets de greffe en inhibant l'activité c-Rel, et de réguler le c-Rel dans le cadre d'applications de recherche et de criblage de nouveaux médicaments.