N-phenyl-2-ethylaminobenzamide | 17761-73-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-2-ethylaminobenzamide
• 英文别名: 2-Ethylamino-benzamid；2-Ethylamino-benzanilid；N-ethyl-anthranilic acid anilide；N-Aethyl-anthranilsaeure-anilid；2-(ethylamino)-N-phenylbenzamide
• CAS: 17761-73-8
• 化学式: C₁₅H₁₆N₂O
• mdl: MFCD00958357
• 分子量: 240.305
• InChiKey: NMMQJVUTAQUOJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-phenyl-2-ethylaminobenzamide 、 乙酸酐 以68%的产率得到N-Ethyl-N-acetylanthranilic acid anilide
  参考文献：
  名称：

  Investigations in the 4[3H]-quinazolone series

  摘要：

  DOI：

  10.1007/bf00759471
• 作为产物：
  描述：

  N-Ethyl-N-acetylanthranilic acid anilide 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 N-phenyl-2-ethylaminobenzamide
  参考文献：
  名称：

  Investigations in the 4[3H]-quinazolone series

  摘要：

  DOI：

  10.1007/bf00759471

文献信息

• Carbon dioxide: a reagent for the simultaneous protection of nucleophilic centres and the activation of alternative locations to electrophilic attack.
  作者：Alan R. Katritzky、Wei-Qiang Fan、Kunihiko Akutagawa

  DOI：10.1016/s0040-4020(01)87558-x

  日期：1986.1

  N-Methyl- and M-ethyl-aniline are regiospecifically converted into a range of ortho-substituted derivatives, using carbon dioxide both for M-protection and as an intermediate carbanion stabilizing group, and -butyllithium to lithiate the ortho-carbon atom. The resulting lithium N-(ortho-substituted-phenyl)-N-methyl- and -N-ethyl-carbamates undergo smooth acid-catalysed decarboxylation under mild conditions

  N-甲基-和M-乙基苯胺被区域特异性地转化为一系列邻位取代的衍生物，同时使用二氧化碳进行M保护和作为中间的碳负离子稳定基团，同时使用丁基丁基锂对邻碳原子进行锂化。所得的N-（邻取代苯基）-N-甲基氨基甲酸锂和-N-乙基氨基甲酸锂在温和的条件下经历平滑的酸催化脱羧作用。没有检测到α-取代的产物。
• INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY
  申请人：Gillet Daniel

  公开号：US20110201601A1

  公开（公告）日：2011-08-18

  The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.

  本发明涉及使用一般式(I)和(II)化合物制备一种药物，用于预防和/或治疗由志贺毒素和相关毒素引起的疾病。
• COMPOUNDS WHICH HAVE A PROTECTIVE ACTIVITY WITH RESPECT TO THE ACTION OF TOXINS AND OF VIRUSES WITH AN INTRACELLULAR MODE OF ACTION
  申请人：Commissariat A L'Energie Atomique Et Aux Energies Alternatives

  公开号：US20160083355A1

  公开（公告）日：2016-03-24

  The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.

  本发明的主题是新型化合物家族，其中包括芳香胺、亚胺、氨基金刚烷和苯二氮卓衍生物，包括相同的药物和将其用作抑制具有细胞内活性的毒素（例如蓖麻毒素）以及利用内化途径感染细胞的病毒的药物。
• Novel compounds which have a protective activity with respect to the action of toxins and of viruses with an intracellular mode of action
  申请人：Lopez Roman

  公开号：US20120283249A1

  公开（公告）日：2012-11-08

  The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.

  本发明涉及新型化合物家族，这些化合物是芳香胺，亚胺，氨基金刚烷和苯二氮平衍生物，包括这些化合物的药物和将其用作抑制具有细胞内活性的毒素（例如蓖麻毒素）和使用内化途径感染细胞的病毒的毒性作用的药物。
• Lockemann; Neumann, Chemische Berichte, 1947, vol. 80, p. 310,315
  作者：Lockemann、Neumann

  DOI：——

  日期：——