2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)succinic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)succinic acid
• 英文别名: 2-(3-oxo-1H-isoindol-2-yl)butanedioic acid
• 化学式: C₁₂H₁₁NO₅
• 分子量: 249.22
• InChiKey: ARQVQTROBUYMIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  94.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Nanopore Method for Identifying Single Amino Acid in Oligopeptides
  申请人：University of South Carolina

  公开号：US20210372959A1

  公开（公告）日：2021-12-02

  The current disclosure provides a transformative concept based on nanopore technology, Sequencing-by-Hydrolysis, to identify the N-terminal amino acid and the length of each peptide fragment in a peptide ladder to reconstitute the sequence of a protein: a protein/peptide analyte will be nonspecifically hydrolyzed to generate random fragments of the analyte that are different by one amino acid with the N-terminal amino acid of each fragment modified so it generates a distinguishable fingerprint signal when tested by nanopore. The length of the fragment can be estimated by characterizing its translocation signal to back calculate the location of the amino acid in the original analyte. This approach will significantly advance the nanopore technology with single amino acid resolution for protein/peptide sequencing.