LAAQ | 1610413-76-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: LAAQ
• 英文别名: (2S)-2-[(3S)-3-methyl-4-[(2S)-2-[(3S)-3-(2-methylpropyl)-2-oxopiperazin-1-yl]propanoyl]-2-oxopiperazin-1-yl]pentanediamide
• CAS: 1610413-76-7
• 化学式: C₂₁H₃₆N₆O₅
• 分子量: 452.554
• InChiKey: YEBKYELGCCUUEX-VGWMRTNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  159
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-溴乙醇 、 Fmoc-L-丙氨酸 、 Fmoc-L-亮氨酸 、 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-8-[4-[[4-(3-methoxy-3-oxopropyl)sulfanyl-4-oxobutanoyl]amino]butyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid 在 哌啶 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 LAAQ
  参考文献：
  名称：

  Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein–Protein Interactions

  摘要：

  Protein-protein interactions encompass large surface areas, but often a handful of key residues dominate the binding energy landscape. Rationally designed small molecule scaffolds that reproduce the relative positioning and disposition of important binding residues, termed "hotspot residues", have been shown to successfully inhibit specific protein complexes. Although this strategy has led to development of novel synthetic inhibitors of protein complexes, often direct mimicry of natural amino acid residues does not lead to potent inhibitors. Experimental screening of focused compound libraries is used to further optimize inhibitors but the number of possible designs that can be efficiently synthesized and experimentally tested in academic settings is limited. We have applied the principles of computational protein design to optimization of nonpeptidic helix mimics as ligands for protein complexes. We describe the development of computational tools to design helix mimetics from canonical and noncanonical residue libraries and their application to two therapeutically important protein-protein interactions: p53-MDM2 and p300-HIF1 alpha. The overall study provides a streamlined approach for discovering potent peptidomimetic inhibitors of protein-protein interactions.

  DOI：

  10.1021/ja502310r

文献信息

• Oxopiperazine helix mimetics for control of Hypoxia-Inducible gene expression
  申请人：NEW YORK UNIVERSITY

  公开号：US10787424B2

  公开（公告）日：2020-09-29

  The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1a with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).

  本发明涉及可模拟 HIF1α C 端转录激活结构域的螺旋 αB 的氧哌嗪类化合物。本发明还公开了含有这些氧化哌嗪的药物组合物和使用这些氧化哌嗪的方法（例如，减少基因转录、治疗或预防由 HIF1a 与 CREB 结合蛋白和/或 p300 的相互作用介导的疾病、减少或预防组织中的血管生成、诱导细胞凋亡以及减少细胞存活和/或增殖）。
• Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein–Protein Interactions
  作者：Brooke Bullock Lao、Kevin Drew、Danielle A. Guarracino、Thomas F. Brewer、Daniel W. Heindel、Richard Bonneau、Paramjit S. Arora

  DOI：10.1021/ja502310r

  日期：2014.6.4

  Protein-protein interactions encompass large surface areas, but often a handful of key residues dominate the binding energy landscape. Rationally designed small molecule scaffolds that reproduce the relative positioning and disposition of important binding residues, termed "hotspot residues", have been shown to successfully inhibit specific protein complexes. Although this strategy has led to development of novel synthetic inhibitors of protein complexes, often direct mimicry of natural amino acid residues does not lead to potent inhibitors. Experimental screening of focused compound libraries is used to further optimize inhibitors but the number of possible designs that can be efficiently synthesized and experimentally tested in academic settings is limited. We have applied the principles of computational protein design to optimization of nonpeptidic helix mimics as ligands for protein complexes. We describe the development of computational tools to design helix mimetics from canonical and noncanonical residue libraries and their application to two therapeutically important protein-protein interactions: p53-MDM2 and p300-HIF1 alpha. The overall study provides a streamlined approach for discovering potent peptidomimetic inhibitors of protein-protein interactions.
• OXOPIPERAZINE HELIX MIMETICS FOR CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION
  申请人：ARORA Paramjit S.

  公开号：US20170190673A1

  公开（公告）日：2017-07-06

  The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1a with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).