3-chloro-5-methylimidazo[1,2-a]pyridine | 334711-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 3-chloro-5-methylimidazo[1,2-a]pyridine
• CAS: 334711-68-1
• 化学式: C₈H₇ClN₂
• 分子量: 166.61
• InChiKey: NTXUDLSLVUMIKK-UHFFFAOYSA-N

物化性质

• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险性防范说明：
  P264,P270,P301+P312,P330,P501
• 危险性描述：
  H302

反应信息

• 作为反应物：
  描述：

  3-chloro-5-methylimidazo[1,2-a]pyridine 在 N-氯代丁二酰亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以32%的产率得到3-Chloro-5-chloromethyl-imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Reactions with N-Chlorosuccinimide of Various 5-Methylimidazo[1,2-a]pyridine Derivatives with an Electron-withdrawing Group Substituted at the 3-Position

  摘要：

  Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.

  DOI：

  10.3987/com-00-9063
• 作为产物：
  描述：

  5-甲基咪唑并[1,2-a]吡啶 在 N-氯代丁二酰亚胺 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以48%的产率得到3-chloro-5-methylimidazo[1,2-a]pyridine
  参考文献：
  名称：

  Reactions with N-Chlorosuccinimide of Various 5-Methylimidazo[1,2-a]pyridine Derivatives with an Electron-withdrawing Group Substituted at the 3-Position

  摘要：

  Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.

  DOI：

  10.3987/com-00-9063

文献信息

• Reactions with N-Chlorosuccinimide of Various 5-Methylimidazo[1,2-a]pyridine Derivatives with an Electron-withdrawing Group Substituted at the 3-Position
  作者：Tomomi Ikemoto、Mitsuhiro Wakimasu

  DOI：10.3987/com-00-9063

  日期：——

  Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.