N-formyl-Met-Ala

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-formyl-Met-Ala
• 英文别名: (2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]propanoic acid
• 化学式: C₉H₁₆N₂O₄S
• mdl: MFCD00057572
• 分子量: 248.303
• InChiKey: GBWVAAKKEIOROG-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Synthesis and recovery of aspartame involving enzymatic deformylation step
  申请人：Holland Sweetener Company V.O.F.

  公开号：EP1013663A1

  公开（公告）日：2000-06-28

  The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-α-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl-α- and β-L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

  本发明涉及天冬酰胺的合成，包括用具有甲酰基蛋氨酰肽变形酶活性的酶处理 N-甲酰基-α-L-天冬氨酰-L-苯丙氨酸化合物，并用 5 至 11 个二价金属离子作为辅助因子基团，使其酶促变形。本发明还涉及用这种酶处理从 N-甲酰基-α-和 β-L-天冬氨酰-L-苯丙氨酸化合物混合物中选择性制备和回收阿斯巴甜。最后，本发明涉及由 N-甲酰基-L-天冬氨酸和 L-或 D,L-苯丙氨酸甲酯通过酶促脱甲酰反应和酶促偶联反应一次酶法合成天冬酰胺，以及通过同时进行酶促偶联反应和脱甲酰反应一次酶法合成二肽或寡肽。
• Preparation of purified peptide deformylase
  申请人：DSM IP Assets B.V.

  公开号：EP2172545A1

  公开（公告）日：2010-04-07

  The invention relates to a method for preparing a purified peptide deformylase, comprising contacting a liquid which comprises a peptide deformylase containing an ionic tag and at least one other enzyme with an ion exchange material to which material the ionic tag binds by ionic interaction and separating the other enzyme from said peptide deformylase. The invention further provides a peptide deformylase comprising an ionic tag, a vector comprising a nucleic acid sequence encoding such a peptide deformylase and a cell comprising such a vector.

  本发明涉及一种制备纯化多肽变形酶的方法，包括将包含含有离子标签的多肽变形酶和至少一种其它酶的液体与离子交换材料接触，离子标签通过离子相互作用与该材料结合，并将其它酶与所述多肽变形酶分离。本发明进一步提供了一种包含离子标签的多肽变形酶、一种包含编码这种多肽变形酶的核酸序列的载体和一种包含这种载体的细胞。
• Theranostics platform and methods of use
  申请人：Sanford Burnham Prebys Medical Discovery Institute

  公开号：US10161929B2

  公开（公告）日：2018-12-25

  Theranostics platforms for identifying drugs and nutraceuticals for treatment of rare disease are described. The platforms comprise (a) a cell-phenotype image-enhancing instrument; (b) a drug/nutraceutical library; and (c) a computer-implemented system for analyzing a response of an optically-visible rare-disease cell phenotype to a drug or nutraceutical from the drug/nutraceutical library.

  本文描述了用于识别治疗罕见病的药物和营养保健品的血清学平台。这些平台包括：(a) 细胞表型图像增强仪器；(b) 药物/营养保健品库；(c) 计算机实施系统，用于分析光学可视罕见疾病细胞表型对药物/营养保健品库中药物或营养保健品的反应。
• SYNTHESIS AND RECOVERY OF ASPARTAME INVOLVING ENZYMATIC DEFORMYLATION STEP
  申请人：Holland Sweetener Company V.o.F.

  公开号：EP1140982B1

  公开（公告）日：2003-04-23
• Methods and compositions for treating metabolic disorders
  申请人：Mootha Vamsi Krishna

  公开号：US20090143279A1

  公开（公告）日：2009-06-04

  The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment metabolic diseases and neurodegenerative diseases. The methods are also useful to increase oxidative phosphorylation or to decrease reactive oxygen species (ROS) production in a subject in need thereof.