2,3-Di(octadec-9-enoyloxy)propyl-trimethylazanium;methyl sulfate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,3-Di(octadec-9-enoyloxy)propyl-trimethylazanium;methyl sulfate
• 英文别名: 2,3-di(octadec-9-enoyloxy)propyl-trimethylazanium;methyl sulfate
• 化学式: C43H83NO8S
• 分子量: 774.2
• InChiKey: RSMRWWHFJMENJH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  11.32
• 重原子数：
  53
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] CARRIERS FOR THE DELIVERY OF NUCLEIC ACIDS TO CELLS AND METHODS OF USE THEREOF<br/>[FR] VÉHICULES POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES À DES CELLULES ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：UNIV UTAH RES FOUND

  公开号：WO2010062502A1

  公开（公告）日：2010-06-03

  Described herein are compounds and methods useful for the delivery of nucleic acids to cells. The compounds and methods are useful in delivering all types of nucleic acids to cells including sensitive nucleic acids such as, for example, siRNA.

  本文描述了用于将核酸传递到细胞的化合物和方法。这些化合物和方法可用于将各种类型的核酸传递到细胞中，包括敏感的核酸，例如siRNA。
• Cells having a spectral signature, and methods of preparation and use thereof
  申请人：Life Technologies Corporation

  公开号：EP2085781A1

  公开（公告）日：2009-08-05

  Methods, compositions and articles of manufacture for encoding a cell with semiconductor nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to functional assays in mixed populations, and an assay result can be determined and associated with individual cells by virtue of their code. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. The methods are used in screening methods for G protein coupled receptors (GPCRs), for identifying the ligands and functions of orphan GPCRs, and for screening for modulators of GPCRs. Kits comprising reagents for performing such methods are also provided.

  本文提供了用半导体纳米晶体和/或其他荧光粉对细胞进行编码的方法、组合物和制造品。编码细胞可在混合群体中进行功能检测，检测结果可根据编码确定并与单个细胞相关联。这些方法在需要对多个编码细胞进行检测的多重环境中特别有用。这些方法可用于 G 蛋白偶联受体（GPCR）的筛选方法，用于鉴定孤儿 GPCR 的配体和功能，以及用于筛选 GPCR 的调节剂。此外，还提供了包含用于执行此类方法的试剂的试剂盒。
• Fragment ligated inhibitors selective for the polo box domain of PLK1
  申请人：University of South Carolina

  公开号：US10067131B2

  公开（公告）日：2018-09-04

  Methods for developing non-peptidic inhibitors that target the polo-box domain of PLK1 proteins are described. Methods include developing structure activity relationships for peptidic inhibitors followed by development of non-peptide fragment alternatives for portions of the peptide inhibitors. The non-peptide fragment can provide similar structure activity relationship as the replaced peptide. Fragment alternatives to key binding determinants are identified in an iterative computational and synthetic process facilitated through understanding of the peptide structure-activity relationships. The approach is informed by peptide structure-activity data obtained through synthesis and testing of truncated and mutated analogs of known PBD binding motifs.

  本文介绍了针对 PLK1 蛋白的 polo-box 结构域开发非肽抑制剂的方法。方法包括开发多肽抑制剂的结构活性关系，然后开发替代部分多肽抑制剂的非肽片段。非肽片段可以提供与被替代肽相似的结构活性关系。关键结合决定因素的片段替代品是在迭代计算和合成过程中通过了解肽的结构-活性关系确定的。该方法参考了通过合成和测试已知 PBD 结合基团的截短和突变类似物获得的肽结构-活性数据。
• Micelles comprising semiconductor nanocrystals and uses thereof
  申请人：——

  公开号：US20040023261A1

  公开（公告）日：2004-02-05

  Methods, compositions and articles of manufacture for encoding a cell with semiconductor nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to functional assays in mixed populations, and an assay result can be determined and associated with individual cells by virtue of their code. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. The methods are used in screening methods for G protein coupled receptors (GPCRs), for identifying the ligands and functions of orphan GPCRs, and for screening for modulators of GPCRs. Kits comprising reagents for performing such methods are also provided.

  本文提供了用半导体纳米晶体和/或其他荧光粉对细胞进行编码的方法、组合物和制造品。编码细胞可在混合群体中进行功能检测，检测结果可根据编码确定并与单个细胞相关联。这些方法在需要对多个编码细胞进行检测的多重环境中特别有用。这些方法可用于 G 蛋白偶联受体（GPCR）的筛选方法，用于鉴定孤儿 GPCR 的配体和功能，以及用于筛选 GPCR 的调节剂。此外，还提供了包含用于执行此类方法的试剂的试剂盒。
• Method for enhancing transport of semiconductor nanocrystals across biological membranes
  申请人：Bruchez P. Marcel

  公开号：US20050059031A1

  公开（公告）日：2005-03-17

  Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of semiconductor nanoparticles across biological membranes to provide encoded cells. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. Kits comprising reagents for performing such methods are also provided.

  描述了由半导体纳米粒子与阳离子聚合物组成的半导体纳米粒子复合物。还描述了增强半导体纳米粒子跨生物膜传输以提供编码细胞的方法。这些方法在需要检测多个编码细胞的多重环境中特别有用。还提供了包含用于执行此类方法的试剂的试剂盒。