2-tert-Butyl-hexahydro-isoindole-1,3-dione | 83248-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-tert-Butyl-hexahydro-isoindole-1,3-dione
• 英文别名: 2-Tert-butyl-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
• CAS: 83248-52-6
• 化学式: C₁₂H₁₉NO₂
• 分子量: 209.288
• InChiKey: VVUAROIPLMALEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-tert-Butyl-hexahydro-isoindole-1,3-dione 、 碘甲烷 在 lithium diisopropyl amide 作用下， 生成 (3aS,7aR)-2-tert-Butyl-3a,7a-dimethyl-hexahydro-isoindole-1,3-dione
  参考文献：
  名称：

  Comparative study of the reactions of dilithiated vicinal diesters and dilithiated 1,2-dicarboximides with methyl iodide, .alpha.,.omega.-dihalides, .alpha.,.omega.-ditosylates and .omega.-bromo esters

  摘要：

  DOI：

  10.1021/jo00145a024
• 作为产物：
  描述：

  叔丁胺 、 1,2-cis-cyclohexanedicarboxylic anhydride 以 溶剂黄146 为溶剂， 反应 40.0h， 以75%的产率得到2-tert-Butyl-hexahydro-isoindole-1,3-dione
  参考文献：
  名称：

  Comparative study of the reactions of dilithiated vicinal diesters and dilithiated 1,2-dicarboximides with methyl iodide, .alpha.,.omega.-dihalides, .alpha.,.omega.-ditosylates and .omega.-bromo esters

  摘要：

  DOI：

  10.1021/jo00145a024

文献信息

• Alignment layer composition, liquid crystal display including the alignment layer composition, and manufacturing method of the liquid crystal display
  申请人：Samsung Display Co. Ltd.

  公开号：US10745622B2

  公开（公告）日：2020-08-18

  An alignment layer composition including a copolymer of a dianhydride compound and a diamine compound, wherein the copolymer includes a repeating unit represented by Formula 1: wherein each of Ar1 and Ar2 is independently a substituted or unsubstituted aromatic group comprising 6 to 30 carbon atoms, X is an electron donating group, and is an ester group, wherein “*” indicates a point of attachment to the aromatic groups Ar1 and Ar2.

  一种配位层组合物，包括二酐化合物和二胺化合物的共聚物，其中共聚物包括由式 1 表示的重复单元： 其中 Ar1 和 Ar2 各自独立地为包含 6 至 30 个碳原子的取代或未取代的芳香基团， X 为电子捐赠基团，以及 是酯基，其中 "*"表示与芳香基团 Ar1 和 Ar2 的连接点。
• ALIGNMENT LAYER COMPOSITION, LIQUID CRYSTAL DISPLAY INCLUDING THE ALIGNMENT LAYER COMPOSITION, AND MANUFACTURING METHOD OF THE LIQUID CRYSTAL DISPLAY
  申请人：Samsung Display Co. Ltd.

  公开号：US20170306236A1

  公开（公告）日：2017-10-26

  An alignment layer composition including a copolymer of a dianhydride compound and a diamine compound, wherein the copolymer includes a repeating unit represented by Formula 1: wherein each of Ar 1 and Ar 2 is independently a substituted or unsubstituted aromatic group comprising 6 to 30 carbon atoms, X is an electron donating group, and is an ester group, wherein “*” indicates a point of attachment to the aromatic groups Ar 1 and Ar 2 .
• US9909066B2
  申请人：——

  公开号：US9909066B2

  公开（公告）日：2018-03-06
• [EN] MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE<br/>[FR] COMPOSÉS MACROCYCLIQUES ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES
  申请人：NOVARTIS AG

  公开号：WO2020128925A1

  公开（公告）日：2020-06-25

  The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.