3,3-dibenzyl-1-(2,4-dichlorobenzoyl)thiourea | 301157-41-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-dibenzyl-1-(2,4-dichlorobenzoyl)thiourea
• 英文别名: 2,4-dichloro-N-(dibenzylcarbamothioyl)benzamide
• CAS: 301157-41-5
• 化学式: C₂₂H₁₈Cl₂N₂OS
• mdl: MFCD00693891
• 分子量: 429.37
• InChiKey: WOQACIUOGYPTNV-UHFFFAOYSA-N

物化性质

• 密度：
  1.340±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  nickel chloride hexahydrate 、 3,3-dibenzyl-1-(2,4-dichlorobenzoyl)thiourea 在 sodium acetate 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以70%的产率得到
  参考文献：
  名称：

  Synthesis, structure, DNA and protein binding studies, and cytotoxic activity of nickel(II) complexes containing 3,3-dialkyl/aryl-1-(2,4-dichlorobenzoyl)thiourea ligands

  摘要：

  A new series of nickel(II) complexes of the type [Ni(L)(2)] (1-6) has been synthesized by using the 3,3-dialkyliaryl-1-(2,4-dichlorobenzoyl)thiourea ligands, and characterized by analytical and spectral (NMR, FT-IR and UV-Vis) techniques. The structures of the ligands (HL1, HL2 and HL3) and complexes (2 and 5) have been confirmed by single crystal X-ray diffraction studies. The interaction of the nickel(II) complexes (2-5) with calf thymus (CT) DNA and bovine serum albumin (BSA) protein was investigated using UV-Vis and fluorescence spectroscopic methods. Absorption and emission spectral studies indicate that complex 2 interacts with CT DNA and BSA protein more strongly than the other complexes (3, 4 and 5). Complexes 2 and 5 exhibited good cytotoxicity against A549 and HT29 cell lines at 50 mu M concentration. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.03.010
• 作为产物：
  描述：

  2,4-二氯苯甲酰氯 以 丙酮 为溶剂， 反应 2.75h， 生成 3,3-dibenzyl-1-(2,4-dichlorobenzoyl)thiourea
  参考文献：
  名称：

  Synthesis, structure, DNA and protein binding studies, and cytotoxic activity of nickel(II) complexes containing 3,3-dialkyl/aryl-1-(2,4-dichlorobenzoyl)thiourea ligands

  摘要：

  A new series of nickel(II) complexes of the type [Ni(L)(2)] (1-6) has been synthesized by using the 3,3-dialkyliaryl-1-(2,4-dichlorobenzoyl)thiourea ligands, and characterized by analytical and spectral (NMR, FT-IR and UV-Vis) techniques. The structures of the ligands (HL1, HL2 and HL3) and complexes (2 and 5) have been confirmed by single crystal X-ray diffraction studies. The interaction of the nickel(II) complexes (2-5) with calf thymus (CT) DNA and bovine serum albumin (BSA) protein was investigated using UV-Vis and fluorescence spectroscopic methods. Absorption and emission spectral studies indicate that complex 2 interacts with CT DNA and BSA protein more strongly than the other complexes (3, 4 and 5). Complexes 2 and 5 exhibited good cytotoxicity against A549 and HT29 cell lines at 50 mu M concentration. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.03.010

文献信息

• Two-component initiator system (amine-free) with very good storage stability and particular suitability for acid systems
  申请人：Utterodt Andreas

  公开号：US20070040151A1

  公开（公告）日：2007-02-22

  A two-component initiator system having accelerators for curing polymerizable materials comprising the following components: (a) a hydroperoxide compound containing one or more hydroperoxide groups that are bound to a tertiary carbon; (b) a thiourea derivative; and (c) as accelerator, a copper compound which is soluble in the preparation is preferably free of amine and is particularly suited for polymerizable dental compositions.
• Synthesis, structure, DNA and protein binding studies, and cytotoxic activity of nickel(II) complexes containing 3,3-dialkyl/aryl-1-(2,4-dichlorobenzoyl)thiourea ligands
  作者：N. Selvakumaran、N.S.P. Bhuvanesh、A. Endo、R. Karvembu

  DOI：10.1016/j.poly.2014.03.010

  日期：2014.6

  A new series of nickel(II) complexes of the type [Ni(L)(2)] (1-6) has been synthesized by using the 3,3-dialkyliaryl-1-(2,4-dichlorobenzoyl)thiourea ligands, and characterized by analytical and spectral (NMR, FT-IR and UV-Vis) techniques. The structures of the ligands (HL1, HL2 and HL3) and complexes (2 and 5) have been confirmed by single crystal X-ray diffraction studies. The interaction of the nickel(II) complexes (2-5) with calf thymus (CT) DNA and bovine serum albumin (BSA) protein was investigated using UV-Vis and fluorescence spectroscopic methods. Absorption and emission spectral studies indicate that complex 2 interacts with CT DNA and BSA protein more strongly than the other complexes (3, 4 and 5). Complexes 2 and 5 exhibited good cytotoxicity against A549 and HT29 cell lines at 50 mu M concentration. (C) 2014 Elsevier Ltd. All rights reserved.