苯乙酸,a-乙基-a-羟基-,(S)- | 24425-55-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 苯乙酸,a-乙基-a-羟基-,(S)-
• 英文名称: s-Pentylglutathione
• 英文别名: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-pentylsulfanylpropan-2-yl]amino]-5-oxopentanoic acid
• CAS: 24425-55-6
• 化学式: C₁₅H₂₇N₃O₆S
• 分子量: 377.5
• InChiKey: AIOKZAFWWVBSMY-QWRGUYRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  25
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  184
• 氢给体数：
  5
• 氢受体数：
  8

ADMET

代谢

戊基-谷胱甘肽是1-碘戊烷的人体代谢物。

Pentyl-glutathione is a known human metabolite of 1-iodopentane.

来源:NORMAN Suspect List Exchange

文献信息

• Treatment of dandruff
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20020168327A1

  公开（公告）日：2002-11-14

  Dandruff and symptoms of dandruff can be treated using lipophilic agents or lipid precursor and/or promoters to strengthen the scalp. The lipophilic agents or lipid precursor and/or promoters are preferably used in conjunction with an antifungal agent which has activity against Malassezia spp, particularly Malassezia furfur . Suitable antifungal agents include those conventionally used for the treatment of dandruff including, for example, zinc pyrithrone (ZnPTO), octopirox and azole antifungal agents such as climbazole and ketocanazole. The antifungal agents may be used singularly or as a mixture of one or more antifungal agents.

  头皮屑和头皮屑症状可使用亲脂剂或脂质前体和/或促进剂来治疗，以增强头皮的功效。亲脂剂或脂质前体和/或促进剂最好与具有抗马拉色菌活性的抗真菌剂一起使用，特别是 糠秕马拉色菌 .合适的抗真菌剂包括传统上用于治疗头皮屑的抗真菌剂，例如吡蚜酮锌 (ZnPTO)、辛吡罗和唑类抗真菌剂，如爬山唑和酮康唑。这些抗真菌剂可单独使用，也可作为一种或多种抗真菌剂的混合物使用。
• Liposomes for protection against toxic compounds
  申请人：Awasthi Sanjay

  公开号：US20050123594A1

  公开（公告）日：2005-06-09

  Generally, and in one form, the present invention is a method of method of preparing a proteoliposome comprising the step of contacting a liposome with an effective portion of RLIP76 to create a proteoliposome. In another form, the present invention is a proteoliposomal composition comprising a liposome and an effective portion of RLIP76. In yet another form, the present invention is a kit for reducing the concentration of toxic compounds and their by-products comprising an effective dose of a proteoliposome, wherein the proteoliposome is a liposome and an effective portion of RLIP76 and an instructional pamphlet. Applications of the present invention include the protection and treatment of mammals and the environment against the accumulation of toxic compounds. The present invention prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds.

  一般来说，在一种形式中，本发明是一种制备蛋白脂质体的方法，包括将脂质体与有效部分的RLIP76接触以产生蛋白脂质体的步骤。在另一种形式中，本发明是一种蛋白脂质体组合物，包括脂质体和有效部分的 RLIP76。在另一种形式中，本发明是一种用于降低有毒化合物及其副产物浓度的试剂盒，包括有效剂量的蛋白脂质体，其中蛋白脂质体是脂质体和有效部分的 RLIP76 以及说明书。本发明的应用包括保护和治疗哺乳动物和环境，防止有毒化合物的积累。本发明可防止一种或多种有毒化合物的积累，降低有毒化合物的浓度，并防止进一步受到一种或多种有毒化合物的污染。
• DIETARY SUPPLEMENTS COMPRISING VITAMINS AND MINERALS
  申请人：LifeScience Corporation

  公开号：EP0514451B1

  公开（公告）日：1997-01-15
• A PROCESS FOR THE PREPARATION OF GLUTATHIONE S-ACYL DERIVATIVES, COMPOUNDS OBTAINED FROM SAID PROCESS AND AN INTERMEDIATE USEFUL FOR THE PREPARATION THEREOF
  申请人：BOEHRINGER MANNHEIM ITALIA S.P.A.

  公开号：EP0536231A1

  公开（公告）日：1993-04-14
• A PROCESS FOR THE PREPARATION OF GLUTATHIONE S-ACYL DERIVATIVES AND COMPOUNDS OBTAINED FROM SAID PROCESS
  申请人：BOEHRINGER MANNHEIM ITALIA S.P.A.

  公开号：EP0536231B1

  公开（公告）日：1996-10-23