L-Proline, 4-hydroxy-1-(1-oxopropyl)-, (4R)- | 53048-68-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Proline, 4-hydroxy-1-(1-oxopropyl)-, (4R)-
• 英文别名: (2S,4R)-4-hydroxy-1-propanoylpyrrolidine-2-carboxylic acid
• CAS: 53048-68-3
• 化学式: C₈H₁₃NO₄
• 分子量: 187.19
• InChiKey: WDQFANGFRWWMLD-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
  申请人：Oka Takahiro

  公开号：US20070049593A1

  公开（公告）日：2007-03-01

  The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

  本发明涉及一种四环融合杂环化合物，其化学式为[I]，其中每个符号的定义如规范中所述，或其药学上可接受的盐，以及一种丙型肝炎病毒（HCV）聚合酶抑制剂和治疗丙型肝炎的药物，本发明的化合物表现出基于HCV聚合酶抑制活性的抗HCV活性，因此可用作预防或治疗丙型肝炎的药物。
• Compositions pharmaceutiques de type pâtes à l'eau
  申请人：ROUSSEL-UCLAF

  公开号：EP0414605A1

  公开（公告）日：1991-02-27

  Compositions pharmaceutiques caractérisées en ce qu'elles renferment de l'oxyde de zinc et une ou plusieurs anti-enzymes.

  药物组合物，其特点是含有氧化锌和一种或多种抗酶。
• PREVENTIVES OR REMEDIES FOR ATOPIC DERMATITIS
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1304323A1

  公开（公告）日：2003-04-23

  The present invention provides skin epidermal ceramide synthesis accelerators, agents for improving skin epidermal barrier function and agents for preventing or improving atopic dermatitis, which each comprises, as an active ingredient, hydroxyproline or an N-acyl derivative of hydroxyproline, or a salt thereof, and cosmetics for improving skin barrier function or improving atopic dermatitis, which comprises the ceramide synthesis accelerator.

  本发明提供了皮肤表皮神经酰胺合成促进剂、改善皮肤表皮屏障功能的制剂和预防或改善特应性皮炎的制剂，它们作为活性成分均包括羟脯氨酸或羟脯氨酸的 N-酰基衍生物或其盐，以及改善皮肤屏障功能或改善特应性皮炎的化妆品，其中包括神经酰胺合成促进剂。
• PREVENTIVE OR REMEDY FOR BEDSORE
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1547594A1

  公开（公告）日：2005-06-29

  In accordance with the present invention, there are provided a preventive or of preventing or therapeutic agent for decubitus comprising an N-acylated derivative of hydroxyproline or a salt thereof; the above preventive or therapeutic agent wherein the N-acylated derivative of hydroxyproline or a salt thereof is contained in an amount of 0.1 to 15% by weight to the total weight; and the preventive or therapeutic agent for decubitus wherein the N-acylated group of the N-acylated derivative of hydroxyproline is an N-acylated group having 1 to 24 carbon atoms.

  根据本发明，提供了一种预防或治疗褥疮的药剂，包括羟脯氨酸的N-酰化衍生物或其盐；上述预防或治疗药剂中，羟脯氨酸的N-酰化衍生物或其盐的含量为总重量的0.1至15%(按总重量计)；以及上述预防或治疗褥疮剂，其中羟脯氨酸的N-酰化衍生物的N-酰化基团是具有1至24个碳原子的N-酰化基团。
• PERORAL PREPARATION FOR PREVENTION OF OR TREATMENT FOR ATOPIC DERMATITIS
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1559425A1

  公开（公告）日：2005-08-03

  In accordance with the present invention, a peroral preparation, food and drink, feed, food additive or feed additive for prevention or treatment of atopic dermatitis comprising hydroxyproline or N-acylated derivative of hydroxyproline or a salt thereof is able to be provided and, particularly, said peroral preparation, food and drink, feed, food additive or feed additive comprising 0.1 to 90% by weight of hydroxyproline or N-acylated derivative of hydroxyproline or a salt thereof is able to be provided.

  根据本发明，可以提供一种用于预防或治疗特应性皮炎的口服制剂、食品和饮料、饲料、食品添加剂或饲料添加剂，该制剂、食品和饮料、饲料、食品添加剂或饲料添加剂中含有羟脯氨酸或羟脯氨酸的 N-酰化衍生物或其盐，特别是所述口服制剂、食品和饮料、饲料、食品添加剂或饲料添加剂中含有 0.1% 至 90% （按重量计）的羟脯氨酸或羟脯氨酸的 N-酰化衍生物或其盐。