3,3-diphenyl-3,4-dihydroisoquinoline | 1426410-07-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-diphenyl-3,4-dihydroisoquinoline
• 英文别名: 3,3-diphenyl-4H-isoquinoline
• CAS: 1426410-07-2
• 化学式: C₂₁H₁₇N
• 分子量: 283.373
• InChiKey: PHGGDEGVXZFHKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-benzhydrylformamide 在 正丁基锂 、 三乙胺 、 三氯氧磷 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 0.33h， 生成 3,3-diphenyl-3,4-dihydroisoquinoline
  参考文献：
  名称：

  Synthesis of 3,4-Dihydroisoquinolines by Cyclization of 1-Bromo-2-(2-isocyanoalkyl)benzenes with Butyllithium

  摘要：

  A new and convenient method for the preparation of 3,3-disubstituted 3,4-dihydroisoquinolines has been developed. Thus, the reaction of 1-bromo-2-(bromomethyl)benzenes with (1-isocyano-1-lithioalkyl)benzenes, generated by the treatment of (1-isocyanoalkyl)benzenes with butyllithium, in THF at -78 degrees C gave the corresponding 1-(2-aryl-2-isocyanoalkyl)-2-bromobenzenes, which in turn were transformed into the desired products on treatment with butyllithium in THF at -78 degrees C.

  DOI：

  10.3987/com-12-12620

文献信息

• DENDRIMERS CONTAINING LUMINESCENT GOLD(III) COMPOUNDS FOR ORGANIC LIGHT-EMITTING DEVICES AND THEIR PREPARATION
  申请人：The University of Hong Kong

  公开号：EP2820107A1

  公开（公告）日：2015-01-07
• [EN] DENDRIMERS CONTAINING LUMINESCENT GOLD(III) COMPOUNDS FOR ORGANIC LIGHT-EMITTING DEVICES AND THEIR PREPARATION<br/>[FR] DENDRIMÈRES CONTENANT DES COMPOSÉS À BASE D'OR (III) LUMINESCENTS POUR DES DISPOSITIFS ÉLECTROLUMINESCENTS ORGANIQUES ET LEUR PRÉPARATION
  申请人：UNIV HONG KONG

  公开号：WO2013127358A1

  公开（公告）日：2013-09-06

  A novel class of saturated or conjugated dendrimers containing at least one strong σ-donating group coordinated to cyclometalated tridentate gold(III) compounds having the chemical structure depicted by generic formula (I), wherein: (a) [Au] is a cyclometalated tridentate gold(III) group; (b) Unit A is a σ-donating chemical group; (c) Unit B is a central part of the dendrons comprising a branch point of dendrimers; (d) Unit C is optional surface groups or dendrons of the dendrimers; (e) n = 0 or 1.
• Synthesis of 3,4-Dihydroisoquinolines by Cyclization of 1-Bromo-2-(2-isocyanoalkyl)benzenes with Butyllithium
  作者：Kazuhiro Kobayashi、Naoki Matsumoto、Kota Matsumoto

  DOI：10.3987/com-12-12620

  日期：——

  A new and convenient method for the preparation of 3,3-disubstituted 3,4-dihydroisoquinolines has been developed. Thus, the reaction of 1-bromo-2-(bromomethyl)benzenes with (1-isocyano-1-lithioalkyl)benzenes, generated by the treatment of (1-isocyanoalkyl)benzenes with butyllithium, in THF at -78 degrees C gave the corresponding 1-(2-aryl-2-isocyanoalkyl)-2-bromobenzenes, which in turn were transformed into the desired products on treatment with butyllithium in THF at -78 degrees C.