4,5,6,7-Tetrachloro-2-pyrimidin-2-ylisoindole-1,3-dione | 418804-47-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 4,5,6,7-Tetrachloro-2-pyrimidin-2-ylisoindole-1,3-dione
• CAS: 418804-47-4
• 化学式: C₁₂H₃Cl₄N₃O₂
• 分子量: 362.987
• InChiKey: FSCJVRQXBAPCDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3,5-三嗪-2,4,6-三胺,N,N'''-1,2-乙二基二[N-[3-[[4,6-二[丁基(2,2,6,6-四甲基-4-哌啶基)氨基]-1,3,5-三嗪-2-基]氨基]丙基]-N,N''-二丁基-N,N''-二(2,2,6,6-四甲基-4-哌啶基)- 、 四氯苯二甲酸酐 在 溶剂黄146 、 碳酸氢钠 作用下， 反应 6.0h， 生成 4,5,6,7-Tetrachloro-2-pyrimidin-2-ylisoindole-1,3-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of some novel cyclic-imides as hypoglycaemic, anti-hyperlipidemic agents

  摘要：

  Certain new halogenated cyclic-imides related to N-substituted phthalimide moiety were synthesized. Spacers of one or two carbon atom distances were inserted to connect the N-terminus of the cyclic-imide nuclei to the used heteroaryl groups to evaluate the effect of such alteration on biological activity. The synthesized compounds were subjected to hypoglycaemic and anti-hyperlipidemic evaluation. Some of the tested compounds proved to be more potent than the reference drugs glibenclamide and clofibrate. Compound Se remarkably reduced serum glucose level by 55%; while 5c, Se, 7d and 8e reduced total serum cholesterol by 58, 56, 54 and 53%, respectively. Those new cyclic-imides could be considered as useful template for future development to obtain more potent hypoglycaemic and anti-hyperlipidemic agents. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.07.002

文献信息

• Synthesis and biological evaluation of some novel cyclic-imides as hypoglycaemic, anti-hyperlipidemic agents
  作者：Alaa A.-M. Abdel-Aziz、Adel S. El-Azab、Sabry M. Attia、Abdulrahman M. Al-Obaid、Mohamed A. Al-Omar、Hussein I. El-Subbagh

  DOI：10.1016/j.ejmech.2011.07.002

  日期：2011.9

  Certain new halogenated cyclic-imides related to N-substituted phthalimide moiety were synthesized. Spacers of one or two carbon atom distances were inserted to connect the N-terminus of the cyclic-imide nuclei to the used heteroaryl groups to evaluate the effect of such alteration on biological activity. The synthesized compounds were subjected to hypoglycaemic and anti-hyperlipidemic evaluation. Some of the tested compounds proved to be more potent than the reference drugs glibenclamide and clofibrate. Compound Se remarkably reduced serum glucose level by 55%; while 5c, Se, 7d and 8e reduced total serum cholesterol by 58, 56, 54 and 53%, respectively. Those new cyclic-imides could be considered as useful template for future development to obtain more potent hypoglycaemic and anti-hyperlipidemic agents. (C) 2011 Elsevier Masson SAS. All rights reserved.