N-(2-benzyl-8-methoxybenzo[f]quinoxalin-3-yl)acetamide | 1397692-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(2-benzyl-8-methoxybenzo[f]quinoxalin-3-yl)acetamide
• CAS: 1397692-00-0
• 化学式: C₂₂H₁₉N₃O₂
• 分子量: 357.412
• InChiKey: SOSRHPTUGBPPAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-benzyl-8-methoxybenzo[f]quinoxalin-3-yl)acetamide 在 盐酸 、 甲醇 、 三氟化硼 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 17.0h， 生成 12-benzyl-8-hydroxy-2-(4-hydroxybenzyl)-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one
  参考文献：
  名称：

  PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS

  摘要：

  已经需要一种生产v-虫螨菌素化合物的简单过程。描述了一种生产由通式（II）表示的v-虫螨菌素化合物的过程，包括（1）在碱存在下将通式（VIII）的化合物与甲基三苯基膦盐反应以得到通式（IX）表示的化合物的步骤，（2）在由通式（IX）表示的化合物和通式（X）的化合物中选择一个进行环闭合亚甲基交换反应的步骤，其中通式（X）是通式（IX）的化合物，其中氨基用R5保护，然后去保护R4和如有的话，R5，以得到由通式（XIV）表示的v-虫螨胺化合物，（3）将通式（XIV）的化合物与由通式（XV）表示的化合物反应以得到通式（II）的化合物。

  公开号：

  US20120232272A1
• 作为产物：
  描述：

  N-(3-benzyl-5-(4-methoxy-2-vinylphenyl)-6-vinylpyrazin-2-yl)acetamide 在 Hoveyda-Grubbs catalyst second generation 氩 、 silica gel 、 ethyl acetate n-hexane 作用下， 以 1,2-dichloromethane 为溶剂， 反应 33.0h， 以to give N-(2-benzyl-8-methoxybenzo[f]quinoxalin-3-yl)acetamide (11) (277 mg, 775 μmol, 85.8%) as a white solid的产率得到N-(2-benzyl-8-methoxybenzo[f]quinoxalin-3-yl)acetamide
  参考文献：
  名称：

  Substituted pyrazines and a process for producing the same

  摘要：

  描述包括(1)一种通式(VIII)的取代吡嗪化合物，和(2)一种制备通式(VIII)的取代吡嗪化合物的方法，其中R1为氢、卤素、取代或未取代的碳氢基团或取代或未取代的杂环基团，R4为保护基。该方法包括(1)将2-氨基-3,5-二溴-6-氯吡嗪与R1MgX和ZnCl2在钯催化剂的存在下反应，以产生通式(V)的化合物；(2)将通式(V)的化合物与通式(VI)的化合物反应，以产生通式(VII)的化合物；和(3)在钯催化剂的存在下，将通式(VII)的化合物与三丁基(乙烯基)锡反应，得到通式(VIII)的化合物。

  公开号：

  US09346767B2

文献信息

• PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS
  申请人：INOUYE Satoshi

  公开号：US20120232272A1

  公开（公告）日：2012-09-13

  A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R 5 , and then deprotecting R 4 and, if any, R 5 to give a v-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound of general formula (XIV) with a compound represented by general formula (XV) to give the compound of general formula (II).

  已经需要一种生产v-虫螨菌素化合物的简单过程。描述了一种生产由通式（II）表示的v-虫螨菌素化合物的过程，包括（1）在碱存在下将通式（VIII）的化合物与甲基三苯基膦盐反应以得到通式（IX）表示的化合物的步骤，（2）在由通式（IX）表示的化合物和通式（X）的化合物中选择一个进行环闭合亚甲基交换反应的步骤，其中通式（X）是通式（IX）的化合物，其中氨基用R5保护，然后去保护R4和如有的话，R5，以得到由通式（XIV）表示的v-虫螨胺化合物，（3）将通式（XIV）的化合物与由通式（XV）表示的化合物反应以得到通式（II）的化合物。
• Process for producing benzo[f]quinoxaline compounds
  申请人：Inouye Satoshi

  公开号：US08772484B2

  公开（公告）日：2014-07-08

  A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R5, and then deprotecting R4 and, if any, R5 to give a v-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound of general formula (XIV) with a compound represented by general formula (XV) to give the compound of general formula (II).

  一种简单的制备V-辣根蛋白酶化合物的方法已经被期望。本文描述了一种制备V-辣根蛋白酶化合物的方法，其包括：（1）在碱的存在下，将通式（VIII）的化合物与甲基三苯基膦盐反应，得到通式（IX）的化合物；（2）对通式（IX）的化合物或通式（IX）中氨基被R5保护的通式（X）的化合物中的任意一个进行环闭合的交叉烯烃反应，然后去除R4和R5（如果有），得到通式（XIV）的V-辣根胺化合物；（3）将通式（XIV）的化合物与通式（XV）的化合物反应，得到通式（II）的化合物。
• PROCESS FOR PRODUCING V-COELENTERAZINE COMPOUNDS
  申请人：JNC CORPORATION

  公开号：US20150119575A1

  公开（公告）日：2015-04-30

  A simple process for producing ν-coelenterazine compounds has been desired. The invention provides a process for producing a ν-coelenterazine compound represented by general formula (II) which comprises (1) the step of reacting a compound represented by general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound represented by general formula (X) which is the compound represented by general formula (IX) wherein the amino is protected with R 5 , and then deprotecting R 4 and, if any, R 5 to give a ν-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound represented by general formula (XIV) with a compound represented by general formula (XV) to give the compound represented by general formula (II).

  生产ν-光珊瑚蛋白酶素化合物的简单过程一直是人们所期望的。本发明提供了一种生产由通式（II）表示的ν-光珊瑚蛋白酶素化合物的方法，该方法包括以下步骤：（1）在碱的存在下，将由通式（VIII）表示的化合物与甲基三苯基膦盐反应，得到由通式（IX）表示的化合物；（2）在由通式（IX）表示的化合物和由R5保护的通式（X）表示的化合物（其中氨基被保护）中选择任意一个化合物，进行环闭合的交换反应，然后去除R4和R5（如果有的话），得到由通式（XIV）表示的ν-光珊瑚蛋白酶胺化合物；（3）将由通式（XIV）表示的化合物与由通式（XV）表示的化合物反应，得到由通式（II）表示的化合物。
• Process for producing substituted benzo[F]imidazo[1,2-A]quinoxalin-3(11H)-ones
  申请人：JNC Corporation

  公开号：US08975403B2

  公开（公告）日：2015-03-10

  A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R5, and then deprotecting R4 and, if any, R5 to give a v-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound of general formula (XIV) with a compound represented by general formula (XV) to give the compound of general formula (II).

  期望有一个简单的生产v-虫萤光素化合物的过程。本文描述了一种生产v-虫萤光素化合物的过程，该化合物由通式（II）表示，包括（1）将通式（VIII）的化合物与甲基三苯基膦盐在碱存在下反应，得到通式（IX）表示的化合物；（2）在通式（IX）表示的化合物和通式（X）的化合物中选择任意一种进行环闭合的交换反应，其中通式（X）的化合物是通式（IX）的化合物，其中氨基受到R5保护，然后去除R4和（如有）R5的保护基，得到通式（XIV）表示的v-虫萤胺化合物；（3）将通式（XIV）表示的化合物与通式（XV）表示的化合物反应，得到通式（II）表示的化合物。
• Substituted pyrazines and a process for producing the same
  申请人：JNC CORPORATION

  公开号：US09346767B2

  公开（公告）日：2016-05-24

  Described include (1) a substituted pyrazine compound of general formula (VIII): and (2) a process for producing the substituted pyrazine compound of general formula (VIII), where R1 is hydrogen, a halogen, a substituted or unsubstituted hydrocarbon group, or a substituted or unsubstituted heterocyclic group, and R4 is a protecting group. The process comprises (1) the step of reacting 2-amino-3,5-dibromo-6-chloropyrazine with R1MgX and ZnCl2 in the presence of a palladium catalyst to produce a compound of general formula (V); (2) the step of reacting the compound of general formula (V) with a compound of general formula (VI) to produce a compound of general formula (VII); and (3) the step of reacting the compound of formula (VII) with tributyl(vinyl)tin in the presence or a palladium catalyst to given the compound of general formula (VIII).

  描述包括(1)一种通式(VIII)的取代吡嗪化合物，和(2)一种制备通式(VIII)的取代吡嗪化合物的方法，其中R1为氢、卤素、取代或未取代的碳氢基团或取代或未取代的杂环基团，R4为保护基。该方法包括(1)将2-氨基-3,5-二溴-6-氯吡嗪与R1MgX和ZnCl2在钯催化剂的存在下反应，以产生通式(V)的化合物；(2)将通式(V)的化合物与通式(VI)的化合物反应，以产生通式(VII)的化合物；和(3)在钯催化剂的存在下，将通式(VII)的化合物与三丁基(乙烯基)锡反应，得到通式(VIII)的化合物。