2-acetamido-3,4,5,6-tetrafluorobenzoic acid | 38793-88-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-acetamido-3,4,5,6-tetrafluorobenzoic acid
• 英文别名: N-Acetyl-3,4,5,6-tetrafluor-anthranilsaeure；2-Acetylamino-3,4,5,6-tetrafluorobenzoic acid
• CAS: 38793-88-3
• 化学式: C₉H₅F₄NO₃
• 分子量: 251.137
• InChiKey: JZSQIYJMXLNQEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-氨基-3,4,5,6-四氟苯甲酸 、 乙酸酐 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以62%的产率得到2-acetamido-3,4,5,6-tetrafluorobenzoic acid
  参考文献：
  名称：

  配体使游离羧酸的 γ-C(sp3 )-H 烯化。

  摘要：

  我们报告了配体驱动的 γ 位游离羧酸的 CH 活化/烯化。通过分子内迈克尔加成，得到δ-内酯产品。确定了两种不同的配体类别，它们能够实现具有挑战性的钯催化 γ 位游离羧酸的活化。所开发的方案具有广泛的酸性底物和烯烃反应伙伴，并被证明适用于制备有用的规模。报告了通过动力学研究获得的对潜在反应机制的见解。

  DOI：

  10.1002/anie.202002362

文献信息

• 5-amino-6,8-difluoroquinolones as antibacterial agents
  申请人：Warner-Lambert Company

  公开号：US04668680A1

  公开（公告）日：1987-05-26

  Novel 7-piperazino and 7-N-methylpiperazino derivatives of 5-amino-1-cyclopropyl-6,8-dihydro-1,4-dihydro-4-oxoquinoline-3-carboxylic acids as antibacterial agents are described as well as methods for their manaufacture, formulation, and use in treating bacterial infections.

  本发明涉及一种7-哌嗪基和7-N-甲基哌嗪基的5-氨基-1-环丙基-6,8-二氢-1,4-二氢-4-氧喹啉-3-羧酸衍生物，作为抗菌剂，并描述了它们的制备、配制和用于治疗细菌感染的方法。
• 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
  申请人：Warner-Lambert Company

  公开号：US04977154A1

  公开（公告）日：1990-12-11

  Novel 7-piperazine derivatives of 5-amino- and 5-hydroxy-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

  本文介绍了一种新型的抗菌药物，即5-氨基和5-羟基-1-环丙基-1,4-二氢-4-氧喹诺酮-3-羧酸的七元哌嗪衍生物，以及它们的制备、配方和治疗细菌感染的方法。
• 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial
  申请人：Warner-Lambert Company

  公开号：US04822801A1

  公开（公告）日：1989-04-18

  Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

  本文介绍了新型萘啶、喹啉和苯并噁嗪羧酸作为抗菌剂，以及它们的制备、配方和用于治疗细菌感染的方法，包括用于制备抗菌剂的某些新型中间体的描述。
• Antibacterial agents - II
  申请人：Warner-Lambert Company

  公开号：US05097032A1

  公开（公告）日：1992-03-17

  Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

  本文描述了新型萘啶、喹啉和苯并噁嗪羧酸作为抗菌剂，以及其制备、配方和治疗细菌感染的使用方法，包括制备抗菌剂所使用的某些新型中间体的描述。
• Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids; substituted-5-amino-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0172651A1

  公开（公告）日：1986-02-26

  Novel naphthyridine-, quinoline- and benzoxazine carboxylic acids of formula or as antibacterial agents are described as well as methods for their manufacture and formulation. Also disclosed are certain novel intermediates used in the manufacture of the antibacterial agents.

  描述了新颖的式或作为抗菌剂的萘啶、喹啉和苯并噁嗪羧酸及其制造和配制方法。 此外，还公开了用于制造抗菌剂的某些新型中间体。