2-acetylamino-5-bromophenyl-(3-nitro-2-pyridyl)sulfide | 1421278-68-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-acetylamino-5-bromophenyl-(3-nitro-2-pyridyl)sulfide
• 英文别名: N-(4-bromo-2-((3-nitropyridin-2-yl)thio)phenyl)acetamide；N-[4-bromo-2-[(3-nitro-2-pyridyl)sulfanyl]phenyl]acetamide；N-[4-bromo-2-(3-nitropyridin-2-yl)sulfanylphenyl]acetamide
• CAS: 1421278-68-3
• 化学式: C₁₃H₁₀BrN₃O₃S
• 分子量: 368.211
• InChiKey: NTBNRLSFZRKXTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-acetylamino-5-bromophenyl-(3-nitro-2-pyridyl)sulfide 在 potassium hydroxide 作用下， 以 丙酮 为溶剂， 反应 16.0h， 以82%的产率得到7-bromo-10H-benzo[b]pyrido[2,3-e][1,4]thiazine
  参考文献：
  名称：

  [EN] ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF
  [FR] COMPOSÉS HÉTÉROCYCLIQUES ANTI-INFECTIEUX ET LEURS UTILISATIONS

  摘要：

  本发明涉及一种具有公式I的杂环化合物，可用作抗感染剂。本发明还涉及通过给予这些化合物来治疗感染的方法，以及包含这些化合物的药物组合物。

  公开号：

  WO2017222466A1
• 作为产物：
  描述：

  2-acetylaminophenyl-(3-nitro-2-pyridyl)sulfide 在 溴 、 溶剂黄146 作用下， 反应 0.67h， 以70%的产率得到2-acetylamino-5-bromophenyl-(3-nitro-2-pyridyl)sulfide
  参考文献：
  名称：

  Synthesis and antimicrobial activity of novel bis-azaphenothiazines

  摘要：

  N-alkylation of azaphenothiazines using dibromoalkanes or dibromoalkenes did not result in the formation of bis-azaphenothiazines under known conditions such as refluxing, for more than 100 h, with NaNH2/xylene or NaH/toluene. However, when the same reaction was tried with NaH/DMF at -5 A degrees C to r.t., it yielded the desired product in 68-71 % yield. These novel bis-azaphenothiazines containing a suitable alkyl or alkenyl spacer were found to possess moderate to significant antimicrobial activities against three gram positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Staphylococcus epidermis), four gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Klebsiella pneumoniae) as well as four fungi (Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, and Candida albicans). Compounds 2b-d were found to exhibit strong antifungal activity, comparable to the standard drug miconazole against A. niger and A. fumigatus.

  DOI：

  10.1007/s00044-012-0454-7

文献信息

• Anti-infective heterocyclic compounds and uses thereof
  申请人：Bioimics AB

  公开号：US11130741B2

  公开（公告）日：2021-09-28

  The present invention relates to heterocyclic compounds of Formula I useful as anti-infective agents. The present invention further relates to a method of treating an infection by administering such compounds, and to pharmaceutical compositions comprising such compounds.

  本发明涉及可用作抗感染剂的式Ⅰ杂环化合物。本发明还涉及通过施用此类化合物治疗感染的方法，以及包含此类化合物的药物组合物。
• ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：Bioimics AB

  公开号：EP3475277B1

  公开（公告）日：2021-10-20