1-[2,2-[[bis-(2,4-dichlorophenyl)]methoxy]ethyl]-1H-imidazole | 445395-48-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2,2-[[bis-(2,4-dichlorophenyl)]methoxy]ethyl]-1H-imidazole
• 英文别名: 1-[2-[Bis(2,4-dichlorophenyl)methoxy]ethyl]imidazole
• CAS: 445395-48-2
• 化学式: C₁₈H₁₄Cl₄N₂O
• 分子量: 416.134
• InChiKey: OLAZLMCPTXXFLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  咪唑 、 1-[双(2,4-二氯苯基)]甲氧基-2-氯乙烷 在 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.5h， 以98%的产率得到1-[2,2-[[bis-(2,4-dichlorophenyl)]methoxy]ethyl]-1H-imidazole
  参考文献：
  名称：

  1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, New Imidazoles with Potent Activity againstCandida albicansand Dermatophytes. Synthesis, Structure−Activity Relationship, and Molecular Modeling Studies

  摘要：

  New 1-[(3-aryloxy-3-aryl)propyl]-1H-imidazoles were synthesized and evaluated against Candida albicans and dermatophytes in order to develop structure-activity relationships (SARs). Against C. albicans the new imidazoles showed minimal inhibitory concentrations (MICs) comparable to those of ketoconazole, miconazole, and econazole, and were more potent than fluconazole. Several derivatives (10, 12, 14, 18-20, 24, 28, 29, 30, and 34) turned out to be potent inhibitors of C. albicans strains resistant to fluconazole, with MIC values less than 10 mu g/mL. Against dermatophytes strains, compounds 20, 25, and 33 (MIC <= 5 mu g/mL) were equipotent to ketoconazole, econazole, and miconazole. SARs of imidazoles 10-44 were rationalized with reasonable accuracy by a previously developed quantitative pharmacophore for antifungal agents.

  DOI：

  10.1021/jm800009r

文献信息

• Beta-cyclodextrin complexes having anti-mycotic activity
  申请人：Bononi, & C. Gruppo di Ricerca Srl

  公开号：EP0288019A1

  公开（公告）日：1988-10-26

  The econazole and miconazole complexes with β-cyclodextrin show in vitro a good anti-fungine activity with wide spectrum and, if locally applied, are well tolerated and more effective than the corresponding nitrates for the control, in vivo and clinically, of the mycosis as induced from dermatophytes and from Candida albicans.

  益康唑和咪康唑与β-环糊精的复合物在体外显示出良好的抗真菌活性和广谱性，如果局部使用，耐受性良好，在体内和临床上比相应的硝酸盐更有效地控制由皮真菌和白色念珠菌引起的真菌病。
• Anti-fungal powder having enhanced excipient properties
  申请人：Kimberly-Clark Worldwide, Inc.

  公开号：US20030224063A1

  公开（公告）日：2003-12-04

  A body powder is disclosed. The body powder includes a topical anti-fungal agent in combination with at least two excipients. One excipient is a boron nitride particulate material coated with a silicone compound. The other excipient is a fragrance molecularly entrapped within a cyclodextrin compound.

  本发明公开了一种润肤粉。这种身体粉末包括一种局部抗真菌剂和至少两种赋形剂。一种赋形剂是涂有硅酮化合物的氮化硼微粒材料。另一种赋形剂是一种分子包裹在环糊精化合物中的香料。
• Imidazole derivatives having therapeutical activity, process for their preparation and pharmaceutical compositions containing them
  申请人：Bononi, & C. Gruppo di Ricerca Srl

  公开号：EP0277333B1

  公开（公告）日：1991-09-11
• US5104893A
  申请人：——

  公开号：US5104893A

  公开（公告）日：1992-04-14
• US5422347A
  申请人：——

  公开号：US5422347A

  公开（公告）日：1995-06-06