N-(tert-butoxycarbonyl)-(3-bromophenyl)-sulfonamide | 1034175-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(tert-butoxycarbonyl)-(3-bromophenyl)-sulfonamide
• 英文别名: Tert-butyl 3-bromophenylsulfonylcarbamate；tert-butyl N-(3-bromophenyl)sulfonylcarbamate
• CAS: 1034175-17-1
• 化学式: C₁₁H₁₄BrNO₄S
• 分子量: 336.206
• InChiKey: OPPLYKQBWUAXSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(tert-butoxycarbonyl)-(3-bromophenyl)-sulfonamide 、 4-amino-5-fluoro-1-[(1S,3R)-3-hydroxycyclopentyl]pyrimidin-2-one 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 tert-butyl N-[(1S,3S)-3-(4-amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-N-(3-bromophenyl)sulfonylcarbamate
  参考文献：
  名称：

  WO2008/76778

  摘要：

  公开号：

文献信息

• SULFONAMIDE COMPOUNDS AND THE USE
  申请人：OGAWA Masami

  公开号：US20100022601A1

  公开（公告）日：2010-01-28

  The sulfoneamide compounds having the following Formula (1), which can be used as an effective component of a CaSR antagonizing agent useful for prophylaxis and/or treatment of bone disorders including osteoporosis and etc., are provided. The compounds have an excellent activity of promoting PTH secretion. In addition, the compounds are useful as an effective component of a medicament for the prophylaxis and/or treatment of bone disorders such as osteoporosis, bone fracture, hypoparathyroidism and the like.

  提供以下式(1)的磺酰胺化合物，可用作预防或治疗包括骨质疏松症等骨疾病的CaSR拮抗剂的有效成分。这些化合物具有促进PTH分泌的卓越活性。此外，这些化合物还用作预防或治疗骨质疏松症、骨折、低甲状旁腺功能等骨疾病药物的有效成分。
• Design and Application of <scp>Indole‐Based</scp> Allylic Donors for <scp>Pd‐Catalyzed</scp> Decarboxylative Allylation Reactions ^†
  作者：Qing‐Qing Hang、Si‐Jia Liu、Lei Yu、Ting‐Ting Sun、Yu‐Chen Zhang、Guang‐Jian Mei、Feng Shi

  DOI：10.1002/cjoc.202000104

  日期：2020.12

  class of indole‐based allylic donors have been designed and developed for palladium‐catalyzed decarboxylative allylations. In addition, the first application of these indole‐based allylic donors in palladium‐catalyzed decarboxylative [3+2] cycloaddition and allylic amination has been achieved by reacting with isocyanates and sulfonyl amines, respectively. This approach represents the first design of indole‐based

  针对钯催化的脱羧烯丙基化，已经设计并开发了新型的基于吲哚的烯丙基供体。此外，这些基于吲哚的烯丙基供体在钯催化的脱羧[3 + 2]环加成反应和烯丙基胺化中的首次应用是通过分别与异氰酸酯和磺胺反应而实现的。这种方法代表了基于吲哚的烯丙基供体的第一个设计，这有助于解决为钯催化的脱羧烯丙基化反应设计和开发新型基于杂环的烯丙基供体的挑战。而且，这种新型的烯丙基供体在环加成和取代中的应用将为脱羧烯丙基化的研究领域增加新的内容。
• ORGANIC COMPOUNDS
  申请人：Bäschlin Daniel Kaspar

  公开号：US20130012485A1

  公开（公告）日：2013-01-10

  Compounds of the formula (I) are provided: wherein V, W, X, Y, Z, R 3 , R 4 , R 5 , R 6 , R 7 and m are as defined in the specification; and pharmaceutically acceptable salts and prodrugs thereof. The compounds may be useful in the treatment or prevention of various diseases and conditions in which dipeptidylpeptidase-IV (DPP-IV) is implicated.

  提供了化学式（I）的化合物： 其中V、W、X、Y、Z、R3、R4、R5、R6、R7和m的定义如规范中所述；以及其药学上可接受的盐和前药。这些化合物可能在治疗或预防各种与二肽基肽酶-IV（DPP-IV）有关的疾病和病况中有用。
• SULFONAMIDE COMPOUND AND APPLICATION THEREOF
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP2292592A1

  公开（公告）日：2011-03-09

  The sulfoneamide compounds having the following Formula (1), which can be used as an effective component of a CaSR antagonizing agent useful for prophylaxis and/or treatment of bone disorders including osteoporosis and etc., are provided. The compounds have an excellent activity of promoting PTH secretion. In addition, the compounds are useful as an effective component of a medicament for the prophylaxis and/or treatment of bone disorders such as osteoporosis, bone fracture, hypoparathyroidism and the like.

  本发明提供了具有下式（1）的砜酰胺化合物，可用作预防和/或治疗骨质疏松症等骨病的 CaSR 拮抗剂的有效成分。这些化合物具有良好的促进 PTH 分泌的活性。此外，这些化合物还可作为预防和/或治疗骨质疏松症、骨折、甲状旁腺功能减退症等骨病的药物的有效成分。
• WO2008/76778
  申请人：——

  公开号：——

  公开（公告）日：——