1-(2-Oxopyrrolidin-1-yl)-3-(piperidin-1-yl)propan-2-yl hexadecanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-(2-Oxopyrrolidin-1-yl)-3-(piperidin-1-yl)propan-2-yl hexadecanoate
• 英文别名: [1-(2-oxopyrrolidin-1-yl)-3-piperidin-1-ylpropan-2-yl] hexadecanoate
• 化学式: C₂₈H₅₂N₂O₃
• 分子量: 464.7
• InChiKey: QEWCYARYROQEEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  33
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS
  申请人：GRI Bio, Inc.

  公开号：EP3229811B1

  公开（公告）日：2021-02-24
• [EN] PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS<br/>[FR] PRÉVENTION ET TRAITEMENT DE PATHOLOGIES INFLAMMATOIRES
  申请人：GLYCOREGIMMUNE INC

  公开号：WO2016094226A1

  公开（公告）日：2016-06-16

  In accordance with some embodiments herein, methods and compositions for prevention and treatment of inflammatory conditions are provided. In some embodiments, compositions comprising NKT-2 activators, for example miltefosine are provided. In some embodiments, the compositions further comprise sulfatide and/or a RAR agonist. In some embodiments, the compositions comprise activators of Type II NKT cells, and/or inhibitors of Type I NKT cells.