2-ethyl-1-piperidin-4-yl-1H-benzimidazole | 875664-91-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-ethyl-1-piperidin-4-yl-1H-benzimidazole
• 英文别名: 2-ethyl-1-(4-piperidinyl)-1H-Benzimidazole；2-ethyl-1-piperidin-4-ylbenzimidazole
• CAS: 875664-91-8
• 化学式: C₁₄H₁₉N₃
• mdl: MFCD14552075
• 分子量: 229.325
• InChiKey: IGBQZVHOCJOZRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethyl-1-piperidin-4-yl-1H-benzimidazole 、 3-(4-fluorophenylthio)propyl bromide 在 potassium carbonate 、 potassium iodide 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 1.0h， 生成 2-Ethyl-1-{1-[3-(4-fluorophenylsulfanyl)-propyl]-piperidin-4-yl}-1H-benzimidazole
  参考文献：
  名称：

  Alkyl-and piperidine-substituted benzimidazole derivatives

  摘要：

  本发明的一种一般化学式1a的化合物，其中R1、R5、R6、A、B、Y、i、j和m的定义如描述和权利要求中所述。本发明的另一个目的是提供包含药用可接受载体和本发明化合物之一或其药用可接受盐的治疗有效量的制药组合物。

  公开号：

  US20060030590A1
• 作为产物：
  描述：

  在 base 作用下， 生成 2-ethyl-1-piperidin-4-yl-1H-benzimidazole
  参考文献：
  名称：

  New ‘chemical probes’ to examine the role of the hFPRL1 (or ALXR) receptor in inflammation

  摘要：

  We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.043

文献信息

• Quinoline derivatives as neurokinin receptor antagonists
  申请人：Carling William Robert

  公开号：US20090054440A1

  公开（公告）日：2009-02-26

  The present invention relates to substituted quinoline hydrazides of Formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.

  本发明涉及式(I)所示的取代喹啉酰肼：其中R1、R2、R3、R4、R5、X、Y和Z在此定义，包含它们的药物组合物及其在治疗由神经激肽-2和/或神经激肽-3 (NK-3)受体介导的疾病中的用途。因此，这些化合物可用于治疗方法，以抑制和治疗这些疾病。
• ALKYL-AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATES
  申请人：BOEHRINGER INGELHEIM INTERNATIONAL GMBH

  公开号：EP1776356A1

  公开（公告）日：2007-04-25
• US7723360B2
  申请人：——

  公开号：US7723360B2

  公开（公告）日：2010-05-25
• [EN] ALKYL-AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATES<br/>[FR] DERIVES DE BENZIMIDAZOLE A SUBSTITUTION ALKYLE ET PIPERIDINE-
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2006013073A1

  公开（公告）日：2006-02-09

  A compound of general formula (1a) wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
• New ‘chemical probes’ to examine the role of the hFPRL1 (or ALXR) receptor in inflammation
  作者：Mike Frohn、Han Xu、Xiaoming Zou、Catherine Chang、Michele McElvaine、Matthew H. Plant、Min Wong、Philip Tagari、Randall Hungate、Roland W. Bürli

  DOI：10.1016/j.bmcl.2007.09.043

  日期：2007.12

  We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro. (c) 2007 Elsevier Ltd. All rights reserved.