苯佐卡因甲烷硫代磺酸酯 | 212207-24-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯佐卡因甲烷硫代磺酸酯
• 英文名称: benzocaine methanethiosulfonate
• 英文别名: 4-(4-aminophenyl)-4-oxo-3-oxabutyl methanethiosulfonate；2-methylsulfonylsulfanylethyl 4-aminobenzoate
• CAS: 212207-24-4
• 化学式: C₁₀H₁₃NO₄S₂
• 分子量: 275.35
• InChiKey: BFIKQFVRUBGWRC-UHFFFAOYSA-N

物化性质

• 熔点：
  109-110°C
• 溶解度：
  可溶于氯仿（少量）、甲醇（少量）

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  S-(2-羟基乙基)甲烷硫代磺酸酯 、 对氨基苯甲酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以38%的产率得到苯佐卡因甲烷硫代磺酸酯
  参考文献：
  名称：

  SITE-SPECIFIC DRUG DELIVERY

  摘要：

  公开号：

  EP0966304B1

文献信息

• Site-specific drug delivery
  申请人：Dime S. David

  公开号：US20060009375A1

  公开（公告）日：2006-01-12

  Compounds and methods which are useful for the site-specific delivery and localization of drugs are provided. The compounds can be represented by the formula: A-L-D wherein A is an anchoring moiety; L is a linking group; and D is a drug.

  本发明提供了用于特定部位输送和定位药物的化合物和方法。这些化合物可以用公式A-L-D表示，其中A是锚定基团；L是连接基团；D是药物。
• Compositions, methods, systems, and kits for affinity purification
  申请人：Nicol R. Gordon

  公开号：US20070148721A1

  公开（公告）日：2007-06-28

  The invention provides a method of separating proteins and peptides of a sample comprising contacting the sample with a Pd coordination compound. The Pd coordination compound binds to sulfur and/or nitrogen groups and thus is useful for purifying biomolecules comprising cysteine, methionine, histidine amino acids or derivatized amino acids/residues comprising sulfur or nitrogen groups which bind to coordination sites on the Pd coordination compounds. The invention also relates to methods, systems and kits for using the Pd coordination compound.
• US7033765B1
  申请人：——

  公开号：US7033765B1

  公开（公告）日：2006-04-25
• [EN] SITE-SPECIFIC DRUG DELIVERY<br/>[FR] ADMINISTRATION DE MEDICAMENT A SPECIFICITE DE SITE
  申请人：——

  公开号：WO1998036777A1

  公开（公告）日：1998-08-27

  [EN] Compounds and methods which are useful for the site-specific delivery and localization of drugs are provided. The compounds can be represented by the formula: A-L-D wherein A is an anchoring moiety; L is a linking group; and D is a drug.
  [FR] L'invention a trait à des composés et aux méthodes afférentes se révélant des plus utiles en matière d'administration de médicaments à spécificité de site et de localisation de ceux-ci. Ces composés peuvent être représentés par la formule A-L-D dans laquelle A représente une fraction d'ancrage, L, un groupe de liaison et D, le médicament.
• [EN] COMPOSITIONS, METHODS, SYSTEMS, AND KITS FOR AFFINITY PURIFICATION<br/>[FR] COMPOSITIONS, PROCEDES, SYSTEMES, ET KITS POUR PURIFICATION D'AFFINITE
  申请人：AGILENT TECHNOLOGIES INC

  公开号：WO2006026416A1

  公开（公告）日：2006-03-09

  The invention provides a method of separating proteins and peptides of a sample comprising contacting the sample with a Pt coordination compound stably associated with a substrate. The Pt coordination compound binds to sulfur and/or nitrogen groups and thus is useful for purifying biomolecules comprising cysteine, methionine, histidine amino acids or derivatized amino acids/residues comprising sulfur or nitrogen groups which bind to coordination sites on the Pt coordination compounds, including their modified, unmodified, processed and unprocessed forms. Also disclosed are methods, systems and kits for using the Pt coordination compound. In certain embodiments the purified proteins and/or peptides may be analyzed using, for example, mass spectrometry to identify and quantify proteins and/or peptides in a sample, such as a proteome or peptidome.